Tissue expression of SLC36A2 - Summary - The Human Protein Atlas

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SLC36A2

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC36A2
Gene description	Solute carrier family 36 (proton/amino acid symporter), member 2
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (kidney, skeletal muscle)
GTEx:	Group enriched (kidney, skeletal muscle)
FANTOM5:	Group enriched (kidney, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression

Luminal expression in kidney.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA044002 , HPA062229
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (kidney, skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (kidney, skeletal muscle)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (kidney, skeletal muscle)

GENE INFORMATION
Gene name	SLC36A2 (HGNC Symbol)
Synonyms	PAT2, TRAMD1, tramdorin
Description	Solute carrier family 36 (proton/amino acid symporter), member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. [provided by RefSeq, Sep 2010]
Chromosome	5
Cytoband	q33.1
Chromosome location (bp)	151314978 - 151347590
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186335 (version 83.38)
Entrez gene	153201
UniProt	Q495M3 (UniProt - Evidence at protein level)
neXtProt	NX_Q495M3
Antibodypedia	SLC36A2 antibodies

PROTEIN BROWSER

SLC36A2-001	SLC36A2-004	SLC36A2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC36A2-001 ENSP00000334223 ENST00000335244	Q495M3 [Direct mapping] Proton-coupled amino acid transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005280 [hydrogen:amino acid symporter activity] GO:0005774 [vacuolar membrane] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015187 [glycine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015808 [L-alanine transport] GO:0015816 [glycine transport] GO:0015824 [proline transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902600 [hydrogen ion transmembrane transport] Show all	483 aa 53.2 kDa	No	>9
SLC36A2-004 ENSP00000430535 ENST00000521967	E5RJJ5 [Direct mapping] Proton-coupled amino acid transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005280 [hydrogen:amino acid symporter activity] GO:0005774 [vacuolar membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015808 [L-alanine transport] GO:0015816 [glycine transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	395 aa 43.8 kDa	No	8
SLC36A2-005 ENSP00000428634 ENST00000523044	H0YB43 [Direct mapping] Proton-coupled amino acid transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005280 [hydrogen:amino acid symporter activity] GO:0005774 [vacuolar membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015808 [L-alanine transport] GO:0015816 [glycine transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	107 aa 11.4 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.