Expression of THBS2 in cancer - Summary

CANCER ATLAS

Gene description

Thrombospondin 2

Protein class

Cancer-related genes, Disease related genes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB017716

GENE INFORMATION
Gene name	THBS2 (HGNC Symbol)
Synonyms	TSP2
Description	Thrombospondin 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q27
Chromosome location (bp)	169215780 - 169254044
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186340 (version 83.38)
Entrez gene	7058
UniProt	P35442 (UniProt - Evidence at protein level)
neXtProt	NX_P35442
Antibodypedia	THBS2 antibodies

PROTEIN BROWSER

THBS2-001	THBS2-002	THBS2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
THBS2-001 ENSP00000355751 ENST00000366787	P35442 [Direct mapping] Thrombospondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005604 [basement membrane] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0016525 [negative regulation of angiogenesis] GO:0031091 [platelet alpha granule] GO:0051965 [positive regulation of synapse assembly] Show all	1172 aa 130 kDa	Yes	0
THBS2-002 ENSP00000398928 ENST00000435791	Q5RI53 [Direct mapping] Thrombospondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008201 [heparin binding] GO:0016525 [negative regulation of angiogenesis] GO:0031012 [extracellular matrix] Show all	83 aa 9.6 kDa	Yes	0
THBS2-201 ENSP00000482784 ENST00000617924	P35442 [Direct mapping] Thrombospondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0016525 [negative regulation of angiogenesis] GO:0031091 [platelet alpha granule] Show all	1172 aa 130 kDa	Yes	0