Cell atlas - THBS2 - The Human Protein Atlas

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THBS2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear speckles
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	THBS2
Gene description	Thrombospondin 2
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytosol & nuclear speckles.
RNA cell category	Cell line enhanced (ASC TERT1, BJ hTERT+ SV40 Large T+ RasG12V, U-2197, BJ hTERT+ SV40 Large T+, BJ hTERT+)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Nuclear speckles (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. CAB017716 , HPA044304
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+ SV40 Large T+ RasG12V, U-2197, BJ hTERT+ SV40 Large T+, BJ hTERT+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytosol & nuclear speckles.

Main location

Plasma membrane (approved)

Additional location

Nuclear speckles (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
CAB017716	A-431	Plasma membrane
CAB017716	A-431	Cytosol
CAB017716	U-2 OS	Plasma membrane
CAB017716	U-2 OS	Cytosol
CAB017716	U-251 MG	Plasma membrane
CAB017716	U-251 MG	Cytosol
HPA044304	PC-3	Nuclear speckles
HPA044304	PC-3	Plasma membrane
HPA044304	U-2 OS	Nuclear speckles
HPA044304	U-2 OS	Plasma membrane
HPA044304	U-251 MG	Nuclear speckles
HPA044304	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	THBS2 (HGNC Symbol)
Synonyms	TSP2
Description	Thrombospondin 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q27
Chromosome location (bp)	169215780 - 169254044
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186340 (version 83.38)
Entrez gene	7058
UniProt	P35442 (UniProt - Evidence at protein level)
neXtProt	NX_P35442
Antibodypedia	THBS2 antibodies

PROTEIN BROWSER

THBS2-001	THBS2-002	THBS2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
THBS2-001 ENSP00000355751 ENST00000366787	P35442 [Direct mapping] Thrombospondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005604 [basement membrane] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0016525 [negative regulation of angiogenesis] GO:0031091 [platelet alpha granule] GO:0051965 [positive regulation of synapse assembly] Show all	1172 aa 130 kDa	Yes	0
THBS2-002 ENSP00000398928 ENST00000435791	Q5RI53 [Direct mapping] Thrombospondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008201 [heparin binding] GO:0016525 [negative regulation of angiogenesis] GO:0031012 [extracellular matrix] Show all	83 aa 9.6 kDa	Yes	0
THBS2-201 ENSP00000482784 ENST00000617924	P35442 [Direct mapping] Thrombospondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0016525 [negative regulation of angiogenesis] GO:0031091 [platelet alpha granule] Show all	1172 aa 130 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.