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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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RXRA
  • premium

    TISSUE

  • premium

    CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Retinoid X receptor, alpha

Protein class

Cancer-related genes, FDA approved drug targets, Nuclear receptors, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB004565
CAB005352

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cancer cells displayed strong nuclear staining, in some cases accentuated to the nuclear membrane.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Nuclear and cytoplasmic staining in all cancer tissues, strongest staining in skin, urothelial and liver cancers.

GENE INFORMATION

Gene name

RXRA (HGNC Symbol)

Synonyms

NR2B1

Description

Retinoid X receptor, alpha (HGNC Symbol)

Entrez gene summary

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

9

Cytoband

q34.2

Chromosome location (bp)

134317098 - 134440585

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186350 (version 83.38)

Entrez gene

6256

UniProt

P19793 (UniProt - Evidence at protein level)

neXtProt

NX_P19793

Antibodypedia

RXRA antibodies

PROTEIN BROWSER

RXRA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RXRA-002
ENSP00000419692
ENST00000481739
P19793 [Direct mapping]
Retinoic acid receptor RXR-alpha
F1D8Q5 [Target identity:100%; Query identity:100%]
Retinoid X nuclear receptor alpha; Retinoid X receptor, alpha, isoform CRA_b
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001701 [in utero embryonic development]
GO:0001889 [liver development]
GO:0001890 [placenta development]
GO:0001893 [maternal placenta development]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003708 [retinoic acid receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004886 [9-cis retinoic acid receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006766 [vitamin metabolic process]
GO:0006954 [inflammatory response]
GO:0007494 [midgut development]
GO:0007565 [female pregnancy]
GO:0007566 [embryo implantation]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0008134 [transcription factor binding]
GO:0008203 [cholesterol metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010269 [response to selenium ion]
GO:0010467 [gene expression]
GO:0014070 [response to organic cyclic compound]
GO:0015721 [bile acid and bile salt transport]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030424 [axon]
GO:0031103 [axon regeneration]
GO:0031490 [chromatin DNA binding]
GO:0031641 [regulation of myelination]
GO:0032403 [protein complex binding]
GO:0032526 [response to retinoic acid]
GO:0032869 [cellular response to insulin stimulus]
GO:0033189 [response to vitamin A]
GO:0033280 [response to vitamin D]
GO:0035357 [peroxisome proliferator activated receptor signaling pathway]
GO:0042809 [vitamin D receptor binding]
GO:0042974 [retinoic acid receptor binding]
GO:0043010 [camera-type eye development]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044323 [retinoic acid-responsive element binding]
GO:0045471 [response to ethanol]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045994 [positive regulation of translational initiation by iron]
GO:0046982 [protein heterodimerization activity]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051289 [protein homotetramerization]
GO:0051384 [response to glucocorticoid]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060528 [secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0070644 [vitamin D response element binding]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]
Show all
462 aa
50.8 kDa
No 0

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