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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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RXRA
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

RXRA

Gene description

Retinoid X receptor, alpha

Protein class

Cancer-related genes
FDA approved drug targets
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Supported based on 2 antibodies.
CAB004565 , CAB005352
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

RXRA (HGNC Symbol)

Synonyms

NR2B1

Description

Retinoid X receptor, alpha (HGNC Symbol)

Entrez gene summary

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

9

Cytoband

q34.2

Chromosome location (bp)

134317098 - 134440585

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186350 (version 83.38)

Entrez gene

6256

UniProt

P19793 (UniProt - Evidence at protein level)

neXtProt

NX_P19793

Antibodypedia

RXRA antibodies

PROTEIN BROWSER

RXRA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RXRA-002
ENSP00000419692
ENST00000481739
P19793 [Direct mapping]
Retinoic acid receptor RXR-alpha
F1D8Q5 [Target identity:100%; Query identity:100%]
Retinoid X nuclear receptor alpha; Retinoid X receptor, alpha, isoform CRA_b
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001701 [in utero embryonic development]
GO:0001889 [liver development]
GO:0001890 [placenta development]
GO:0001893 [maternal placenta development]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003708 [retinoic acid receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004886 [9-cis retinoic acid receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006766 [vitamin metabolic process]
GO:0006954 [inflammatory response]
GO:0007494 [midgut development]
GO:0007565 [female pregnancy]
GO:0007566 [embryo implantation]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0008134 [transcription factor binding]
GO:0008203 [cholesterol metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010269 [response to selenium ion]
GO:0010467 [gene expression]
GO:0014070 [response to organic cyclic compound]
GO:0015721 [bile acid and bile salt transport]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030424 [axon]
GO:0031103 [axon regeneration]
GO:0031490 [chromatin DNA binding]
GO:0031641 [regulation of myelination]
GO:0032403 [protein complex binding]
GO:0032526 [response to retinoic acid]
GO:0032869 [cellular response to insulin stimulus]
GO:0033189 [response to vitamin A]
GO:0033280 [response to vitamin D]
GO:0035357 [peroxisome proliferator activated receptor signaling pathway]
GO:0042809 [vitamin D receptor binding]
GO:0042974 [retinoic acid receptor binding]
GO:0043010 [camera-type eye development]
GO:0043065 [positive regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044323 [retinoic acid-responsive element binding]
GO:0045471 [response to ethanol]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045994 [positive regulation of translational initiation by iron]
GO:0046982 [protein heterodimerization activity]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051289 [protein homotetramerization]
GO:0051384 [response to glucocorticoid]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060528 [secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0070644 [vitamin D response element binding]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]
Show all
462 aa
50.8 kDa
No 0

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