Expression of KRT10 in cancer - Summary

CANCER ATLAS

Gene description

Keratin 10, type I

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Skin cancer

STAINING SUMMARY

HPA012014	CAB000132

GENE INFORMATION
Gene name	KRT10 (HGNC Symbol)
Synonyms	CK10, K10, KPP
Description	Keratin 10, type I (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	40818117 - 40822595
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186395 (version 83.38)
Entrez gene	3858
UniProt	P13645 (UniProt - Evidence at protein level)
neXtProt	NX_P13645
Antibodypedia	KRT10 antibodies

PROTEIN BROWSER

KRT10-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT10-002 ENSP00000269576 ENST00000269576	P13645 [Direct mapping] Keratin, type I cytoskeletal 10 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005882 [intermediate filament] GO:0016020 [membrane] GO:0030216 [keratinocyte differentiation] GO:0030280 [structural constituent of epidermis] GO:0030855 [epithelial cell differentiation] GO:0045095 [keratin filament] GO:0070062 [extracellular exosome] GO:0071277 [cellular response to calcium ion] Show all	584 aa 58.8 kDa	No	0