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KRT10

GENERAL INFORMATION

Gene name

 KRT10

Gene description

 Keratin 10, type I

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (skin)
GTEx:Tissue enriched (skin)
FANTOM5:Group enriched (endometrium, cervix, uterine)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in squamous epithelium of skin.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA012014 , CAB000132
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (endometrium, cervix, uterine)

GENE INFORMATION

Gene name

 KRT10 (HGNC Symbol)

Synonyms

 CK10, K10, KPP

Description

 Keratin 10, type I (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 40818117 - 40822595

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186395 (version 83.38)

Entrez gene

 3858

UniProt

 P13645 (UniProt - Evidence at protein level)

neXtProt

 NX_P13645

Antibodypedia

 KRT10 antibodies

PROTEIN BROWSER
KRT10-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT10-002
ENSP00000269576
ENST00000269576
P13645 [Direct mapping]
Keratin, type I cytoskeletal 10
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0016020 [membrane]
GO:0030216 [keratinocyte differentiation]
GO:0030280 [structural constituent of epidermis]
GO:0030855 [epithelial cell differentiation]
GO:0045095 [keratin filament]
GO:0070062 [extracellular exosome]
GO:0071277 [cellular response to calcium ion]
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 584 aa
58.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.