We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
A majority of malignant cells were negative or showed weak cytoplasmic and nuclear positivity. A few cases of colorectal, breast, ovarian and urothelial cancers were moderately stained. A single case of seminoma and a few cases of renal adenocarcinomas exhibited strong nuclear staining.
GENE INFORMATION
Gene name
FGF3 (HGNC Symbol)
Synonyms
HBGF-3, INT2
Description
Fibroblast growth factor 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]