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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

Score

Score

Antibodies

Column

 
 
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CCK
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TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CCK

Gene description

Cholecystokinin

Protein class

Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (cerebral cortex, duodenum, prostate)
GTEx:Group enriched (cerebral cortex, hippocampus)
FANTOM5:Group enriched (brain, hippocampus, colon, small intestine, placenta)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression in several tissues, most abundant in glandular cells of gastrointestinal tract and Purkinje cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 1 antibody.
CAB002308
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, duodenum, prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, hippocampus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, hippocampus, colon, small intestine, placenta)

GENE INFORMATION

Gene name

CCK

Synonyms

Description

Cholecystokinin (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Chromosome

3

Cytoband

p22.1

Chromosome location (bp)

42257825 - 42266207

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000187094 (version 83.38)

Entrez gene

885

UniProt

P06307 (UniProt - Evidence at protein level)

neXtProt

NX_P06307

Antibodypedia

CCK antibodies

PROTEIN BROWSER

CCK-001
CCK-002
CCK-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCK-001
ENSP00000335657
ENST00000334681
P06307 [Direct mapping]
Cholecystokinin Cholecystokinin-58 Cholecystokinin-58 desnonopeptide Cholecystokinin-39 Cholecystokinin-33 Cholecystokinin-25 Cholecystokinin-18 Cholecystokinin-12 Cholecystokinin-8 Cholecystokinin-7 Cholecystokinin-5
Q6FG82 [Target identity:100%; Query identity:100%]
CCK protein; Cholecystokinin; Cholecystokinin, isoform CRA_a; cDNA FLJ76519, highly similar to Homo sapiens cholecystokinin (CCK), mRNA
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Show all
GO:0001764 [neuron migration]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0030424 [axon]
GO:0042755 [eating behavior]
Show all
115 aa
12.7 kDa
Yes 0
CCK-002
ENSP00000379472
ENST00000396169
P06307 [Direct mapping]
Cholecystokinin Cholecystokinin-58 Cholecystokinin-58 desnonopeptide Cholecystokinin-39 Cholecystokinin-33 Cholecystokinin-25 Cholecystokinin-18 Cholecystokinin-12 Cholecystokinin-8 Cholecystokinin-7 Cholecystokinin-5
Q6FG82 [Target identity:100%; Query identity:100%]
CCK protein; Cholecystokinin; Cholecystokinin, isoform CRA_a; cDNA FLJ76519, highly similar to Homo sapiens cholecystokinin (CCK), mRNA
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001662 [behavioral fear response]
GO:0001764 [neuron migration]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007409 [axonogenesis]
GO:0008284 [positive regulation of cell proliferation]
GO:0014049 [positive regulation of glutamate secretion]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032099 [negative regulation of appetite]
GO:0032461 [positive regulation of protein oligomerization]
GO:0042755 [eating behavior]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0043195 [terminal bouton]
GO:0043203 [axon hillock]
GO:0043204 [perikaryon]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051901 [positive regulation of mitochondrial depolarization]
GO:0051930 [regulation of sensory perception of pain]
Show all
115 aa
12.7 kDa
Yes 0
CCK-003
ENSP00000409124
ENST00000434608
P06307 [Direct mapping]
Cholecystokinin Cholecystokinin-58 Cholecystokinin-58 desnonopeptide Cholecystokinin-39 Cholecystokinin-33 Cholecystokinin-25 Cholecystokinin-18 Cholecystokinin-12 Cholecystokinin-8 Cholecystokinin-7 Cholecystokinin-5
Q6FG82 [Target identity:100%; Query identity:100%]
CCK protein; Cholecystokinin; Cholecystokinin, isoform CRA_a; cDNA FLJ76519, highly similar to Homo sapiens cholecystokinin (CCK), mRNA
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001764 [neuron migration]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0030424 [axon]
GO:0042755 [eating behavior]
Show all
115 aa
12.7 kDa
Yes 0

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