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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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RNF220
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Ring finger protein 220

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA027578

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of prostate cancers as well as a few cases of breast, liver and endometrial cancers showed moderate to strong granular cytoplasmic positivity. Remaining cancer tissues were negative or weakly stained.

GENE INFORMATION

Gene name

RNF220 (HGNC Symbol)

Synonyms

C1orf164, FLJ10597

Description

Ring finger protein 220 (HGNC Symbol)

Entrez gene summary

Chromosome

1

Cytoband

p34.1

Chromosome location (bp)

44405194 - 44651724

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000187147 (version 83.38)

Entrez gene

55182

UniProt

Q5VTB9 (UniProt - Evidence at protein level)

neXtProt

NX_Q5VTB9

Antibodypedia

RNF220 antibodies

PROTEIN BROWSER

RNF220-001
RNF220-002
RNF220-010
RNF220-013
RNF220-014
RNF220-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RNF220-001
ENSP00000347548
ENST00000355387
Q5VTB9 [Direct mapping]
E3 ubiquitin-protein ligase RNF220
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
566 aa
62.8 kDa
Yes 0
RNF220-002
ENSP00000354872
ENST00000361799
Q5VTB9 [Direct mapping]
E3 ubiquitin-protein ligase RNF220
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0051865 [protein autoubiquitination]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
566 aa
62.8 kDa
Yes 0
RNF220-010
ENSP00000411541
ENST00000453863
H0Y7B1 [Direct mapping]
E3 ubiquitin-protein ligase RNF220
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
121 aa
13.8 kDa
No 0
RNF220-013
ENSP00000388533
ENST00000440132
Q5TDE7 [Direct mapping]
E3 ubiquitin-protein ligase RNF220
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
259 aa
29.3 kDa
No 0
RNF220-014
ENSP00000335580
ENST00000335497
Q5TDE8 [Direct mapping]
E3 ubiquitin-protein ligase RNF220
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
260 aa
29.2 kDa
No 0
RNF220-201
ENSP00000361321
ENST00000372247
Q5VTB9 [Direct mapping]
E3 ubiquitin-protein ligase RNF220
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0051865 [protein autoubiquitination]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
566 aa
62.8 kDa
Yes 0

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The Human Protein Atlas

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.