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SHTN1

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GENERAL INFORMATION

Gene name

 SHTN1

Gene description

 Shootin 1

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the plasma membrane & cytosol.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved)

Additional location

 In addition localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA037943
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the plasma membrane & cytosol.

Main location

 Nucleus (approved)

Additional location

 Plasma membrane (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA037943 A-431 Nucleus
Plasma membrane
Cytosol
HPA037943 U-2 OS Nucleus
Cytosol
HPA037943 U-251 MG Nucleoplasm
Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 SHTN1 (HGNC Symbol)

Synonyms

 KIAA1598, shootin-1, shootin1

Description

 Shootin 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 q25.3

Chromosome location (bp)

 116881482 - 117126586

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187164 (version 83.38)

Entrez gene

 57698

UniProt

 A0MZ66 (UniProt - Evidence at protein level)

neXtProt

 NX_A0MZ66

Antibodypedia

 SHTN1 antibodies

PROTEIN BROWSER
SHTN1-001
SHTN1-201
SHTN1-202
SHTN1-203
SHTN1-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SHTN1-001
ENSP00000480109
ENST00000615301
A0MZ66 [Direct mapping]
Shootin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005875 [microtubule associated complex]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007265 [Ras protein signal transduction]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0015630 [microtubule cytoskeleton]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031252 [cell leading edge]
GO:0032488 [Cdc42 protein signal transduction]
GO:0038007 [netrin-activated signaling pathway]
GO:0043204 [perikaryon]
GO:0044295 [axonal growth cone]
GO:0045773 [positive regulation of axon extension]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0060327 [cytoplasmic actin-based contraction involved in cell motility]
GO:0061163 [endoplasmic reticulum polarization]
GO:0061573 [actin filament bundle retrograde transport]
GO:2000114 [regulation of establishment of cell polarity]
GO:2001224 [positive regulation of neuron migration]
Show all
 456 aa
52.6 kDa 		No 0
SHTN1-201
ENSP00000260777
ENST00000260777
A0MZ66 [Direct mapping]
Shootin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005875 [microtubule associated complex]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007265 [Ras protein signal transduction]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0015630 [microtubule cytoskeleton]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031252 [cell leading edge]
GO:0032488 [Cdc42 protein signal transduction]
GO:0038007 [netrin-activated signaling pathway]
GO:0043204 [perikaryon]
GO:0044295 [axonal growth cone]
GO:0045773 [positive regulation of axon extension]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0060327 [cytoplasmic actin-based contraction involved in cell motility]
GO:0061163 [endoplasmic reticulum polarization]
GO:0061573 [actin filament bundle retrograde transport]
GO:2000114 [regulation of establishment of cell polarity]
GO:2001224 [positive regulation of neuron migration]
Show all
 571 aa
64.5 kDa 		No 0
SHTN1-202
ENSP00000347532
ENST00000355371
A0MZ66 [Direct mapping]
Shootin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005875 [microtubule associated complex]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007265 [Ras protein signal transduction]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0015630 [microtubule cytoskeleton]
GO:0019894 [kinesin binding]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031252 [cell leading edge]
GO:0032488 [Cdc42 protein signal transduction]
GO:0038007 [netrin-activated signaling pathway]
GO:0043204 [perikaryon]
GO:0044295 [axonal growth cone]
GO:0045773 [positive regulation of axon extension]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0060327 [cytoplasmic actin-based contraction involved in cell motility]
GO:0061163 [endoplasmic reticulum polarization]
GO:0061573 [actin filament bundle retrograde transport]
GO:2000114 [regulation of establishment of cell polarity]
GO:2001222 [regulation of neuron migration]
GO:2001224 [positive regulation of neuron migration]
Show all
 631 aa
71.6 kDa 		No 0
SHTN1-203
ENSP00000376635
ENST00000392901
A0MZ66 [Direct mapping]
Shootin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005875 [microtubule associated complex]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007265 [Ras protein signal transduction]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0015630 [microtubule cytoskeleton]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031252 [cell leading edge]
GO:0032488 [Cdc42 protein signal transduction]
GO:0038007 [netrin-activated signaling pathway]
GO:0043204 [perikaryon]
GO:0044295 [axonal growth cone]
GO:0045773 [positive regulation of axon extension]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0060327 [cytoplasmic actin-based contraction involved in cell motility]
GO:0061163 [endoplasmic reticulum polarization]
GO:0061573 [actin filament bundle retrograde transport]
GO:2000114 [regulation of establishment of cell polarity]
GO:2001224 [positive regulation of neuron migration]
Show all
 498 aa
56.4 kDa 		No 0
SHTN1-204
ENSP00000376636
ENST00000392903
A0MZ66 [Direct mapping]
Shootin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005875 [microtubule associated complex]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007265 [Ras protein signal transduction]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0015630 [microtubule cytoskeleton]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031252 [cell leading edge]
GO:0032488 [Cdc42 protein signal transduction]
GO:0038007 [netrin-activated signaling pathway]
GO:0043204 [perikaryon]
GO:0044295 [axonal growth cone]
GO:0045773 [positive regulation of axon extension]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0060327 [cytoplasmic actin-based contraction involved in cell motility]
GO:0061163 [endoplasmic reticulum polarization]
GO:0061573 [actin filament bundle retrograde transport]
GO:2000114 [regulation of establishment of cell polarity]
GO:2001224 [positive regulation of neuron migration]
Show all
 558 aa
63.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.