Fields »
ABOUT
HELP
BLOG
SHTN1

GENERAL INFORMATION

Gene name

 SHTN1

Gene description

 Shootin 1

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (hippocampus)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA037942
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin010203040TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hippocampus)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin020406080RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina050100150200250300350Tags Per Million

GENE INFORMATION

Gene name

 SHTN1 (HGNC Symbol)

Synonyms

 KIAA1598, shootin-1, shootin1

Description

 Shootin 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 q25.3

Chromosome location (bp)

 116881482 - 117126586

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187164 (version 83.38)

Entrez gene

 57698

UniProt

 A0MZ66 (UniProt - Evidence at protein level)

neXtProt

 NX_A0MZ66

Antibodypedia

 SHTN1 antibodies

PROTEIN BROWSER
SHTN1-001
SHTN1-201
SHTN1-202
SHTN1-203
SHTN1-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SHTN1-001
ENSP00000480109
ENST00000615301
A0MZ66 [Direct mapping]
Shootin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005875 [microtubule associated complex]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007265 [Ras protein signal transduction]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0015630 [microtubule cytoskeleton]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031252 [cell leading edge]
GO:0032488 [Cdc42 protein signal transduction]
GO:0038007 [netrin-activated signaling pathway]
GO:0043204 [perikaryon]
GO:0044295 [axonal growth cone]
GO:0045773 [positive regulation of axon extension]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0060327 [cytoplasmic actin-based contraction involved in cell motility]
GO:0061163 [endoplasmic reticulum polarization]
GO:0061573 [actin filament bundle retrograde transport]
GO:2000114 [regulation of establishment of cell polarity]
GO:2001224 [positive regulation of neuron migration]
Show all
 456 aa
52.6 kDa 		No 0
SHTN1-201
ENSP00000260777
ENST00000260777
A0MZ66 [Direct mapping]
Shootin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005875 [microtubule associated complex]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007265 [Ras protein signal transduction]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0015630 [microtubule cytoskeleton]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031252 [cell leading edge]
GO:0032488 [Cdc42 protein signal transduction]
GO:0038007 [netrin-activated signaling pathway]
GO:0043204 [perikaryon]
GO:0044295 [axonal growth cone]
GO:0045773 [positive regulation of axon extension]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0060327 [cytoplasmic actin-based contraction involved in cell motility]
GO:0061163 [endoplasmic reticulum polarization]
GO:0061573 [actin filament bundle retrograde transport]
GO:2000114 [regulation of establishment of cell polarity]
GO:2001224 [positive regulation of neuron migration]
Show all
 571 aa
64.5 kDa 		No 0
SHTN1-202
ENSP00000347532
ENST00000355371
A0MZ66 [Direct mapping]
Shootin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005875 [microtubule associated complex]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007265 [Ras protein signal transduction]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0015630 [microtubule cytoskeleton]
GO:0019894 [kinesin binding]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031252 [cell leading edge]
GO:0032488 [Cdc42 protein signal transduction]
GO:0038007 [netrin-activated signaling pathway]
GO:0043204 [perikaryon]
GO:0044295 [axonal growth cone]
GO:0045773 [positive regulation of axon extension]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0060327 [cytoplasmic actin-based contraction involved in cell motility]
GO:0061163 [endoplasmic reticulum polarization]
GO:0061573 [actin filament bundle retrograde transport]
GO:2000114 [regulation of establishment of cell polarity]
GO:2001222 [regulation of neuron migration]
GO:2001224 [positive regulation of neuron migration]
Show all
 631 aa
71.6 kDa 		No 0
SHTN1-203
ENSP00000376635
ENST00000392901
A0MZ66 [Direct mapping]
Shootin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005875 [microtubule associated complex]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007265 [Ras protein signal transduction]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0015630 [microtubule cytoskeleton]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031252 [cell leading edge]
GO:0032488 [Cdc42 protein signal transduction]
GO:0038007 [netrin-activated signaling pathway]
GO:0043204 [perikaryon]
GO:0044295 [axonal growth cone]
GO:0045773 [positive regulation of axon extension]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0060327 [cytoplasmic actin-based contraction involved in cell motility]
GO:0061163 [endoplasmic reticulum polarization]
GO:0061573 [actin filament bundle retrograde transport]
GO:2000114 [regulation of establishment of cell polarity]
GO:2001224 [positive regulation of neuron migration]
Show all
 498 aa
56.4 kDa 		No 0
SHTN1-204
ENSP00000376636
ENST00000392903
A0MZ66 [Direct mapping]
Shootin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005875 [microtubule associated complex]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007265 [Ras protein signal transduction]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0015630 [microtubule cytoskeleton]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031252 [cell leading edge]
GO:0032488 [Cdc42 protein signal transduction]
GO:0038007 [netrin-activated signaling pathway]
GO:0043204 [perikaryon]
GO:0044295 [axonal growth cone]
GO:0045773 [positive regulation of axon extension]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048812 [neuron projection morphogenesis]
GO:0051015 [actin filament binding]
GO:0060327 [cytoplasmic actin-based contraction involved in cell motility]
GO:0061163 [endoplasmic reticulum polarization]
GO:0061573 [actin filament bundle retrograde transport]
GO:2000114 [regulation of establishment of cell polarity]
GO:2001224 [positive regulation of neuron migration]
Show all
 558 aa
63.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.