Expression of GCNT1 in cancer - Summary

CANCER ATLAS

Gene description

Glucosaminyl (N-acetyl) transferase 1, core 2

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA031151

GENE INFORMATION
Gene name	GCNT1 (HGNC Symbol)
Synonyms	C2GNT, NACGT2, NAGCT2
Description	Glucosaminyl (N-acetyl) transferase 1, core 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q21.13
Chromosome location (bp)	76419850 - 76507416
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187210 (version 83.38)
Entrez gene	2650
UniProt	Q02742 (UniProt - Evidence at protein level)
neXtProt	NX_Q02742
Antibodypedia	GCNT1 antibodies

PROTEIN BROWSER

GCNT1-001	GCNT1-201	GCNT1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GCNT1-001 ENSP00000365920 ENST00000376730	Q02742 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003829 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0006493 [protein O-linked glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0009101 [glycoprotein biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0031985 [Golgi cisterna] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0050901 [leukocyte tethering or rolling] GO:0060352 [cell adhesion molecule production] Show all	428 aa 49.8 kDa	No	0
GCNT1-201 ENSP00000415454 ENST00000442371	Q02742 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003829 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005802 [trans-Golgi network] GO:0006493 [protein O-linked glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0009101 [glycoprotein biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0031985 [Golgi cisterna] GO:0032868 [response to insulin] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048729 [tissue morphogenesis] GO:0050901 [leukocyte tethering or rolling] GO:0060352 [cell adhesion molecule production] GO:0060993 [kidney morphogenesis] Show all	428 aa 49.8 kDa	No	0
GCNT1-202 ENSP00000390703 ENST00000444201	Q02742 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003829 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0006493 [protein O-linked glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0009101 [glycoprotein biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0031985 [Golgi cisterna] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0050901 [leukocyte tethering or rolling] GO:0060352 [cell adhesion molecule production] Show all	428 aa 49.8 kDa	No	0