Cell atlas - GCNT1 - The Human Protein Atlas

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GCNT1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GCNT1
Gene description	Glucosaminyl (N-acetyl) transferase 1, core 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles.
RNA cell category	Cell line enhanced (U-2197)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA003522 , HPA003523
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles.

Main location

Nuclear speckles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA003522	BJ	Nucleoplasm
	HPA003522	BJ	Plasma membrane
	HPA003522	RH-30	Nuclear speckles
	HPA003522	U-2 OS	Nuclear speckles
	HPA003523	RH-30	Nuclear speckles
	HPA003523	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	GCNT1 (HGNC Symbol)
Synonyms	C2GNT, NACGT2, NAGCT2
Description	Glucosaminyl (N-acetyl) transferase 1, core 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q21.13
Chromosome location (bp)	76419850 - 76507416
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187210 (version 83.38)
Entrez gene	2650
UniProt	Q02742 (UniProt - Evidence at protein level)
neXtProt	NX_Q02742
Antibodypedia	GCNT1 antibodies

PROTEIN BROWSER

GCNT1-001	GCNT1-201	GCNT1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GCNT1-001 ENSP00000365920 ENST00000376730	Q02742 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003829 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0006493 [protein O-linked glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0009101 [glycoprotein biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0031985 [Golgi cisterna] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0050901 [leukocyte tethering or rolling] GO:0060352 [cell adhesion molecule production] Show all	428 aa 49.8 kDa	No	0
GCNT1-201 ENSP00000415454 ENST00000442371	Q02742 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003829 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005802 [trans-Golgi network] GO:0006493 [protein O-linked glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0009101 [glycoprotein biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0031985 [Golgi cisterna] GO:0032868 [response to insulin] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048729 [tissue morphogenesis] GO:0050901 [leukocyte tethering or rolling] GO:0060352 [cell adhesion molecule production] GO:0060993 [kidney morphogenesis] Show all	428 aa 49.8 kDa	No	0
GCNT1-202 ENSP00000390703 ENST00000444201	Q02742 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003829 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0006493 [protein O-linked glycosylation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0009101 [glycoprotein biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0031985 [Golgi cisterna] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0050901 [leukocyte tethering or rolling] GO:0060352 [cell adhesion molecule production] Show all	428 aa 49.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.