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Most malignancies displayed weak to moderate cytoplasmic positivity. Additional membranous staining was observed in several cases. Skin cancer and several malignant lymphomas were negative.
GENE INFORMATION
Gene name
CHP1 (HGNC Symbol)
Synonyms
CHP, p22, p24, Sid470p, SLC9A1BP
Description
Calcineurin-like EF-hand protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]