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CHP1

GENERAL INFORMATION

Gene name

 CHP1

Gene description

 Calcineurin-like EF-hand protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression with cytoplasmic expression in several different tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA006616
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CHP1 (HGNC Symbol)

Synonyms

 CHP, p22, p24, Sid470p, SLC9A1BP

Description

 Calcineurin-like EF-hand protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 41230839 - 41281890

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187446 (version 83.38)

Entrez gene

 11261

UniProt

 Q99653 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99653

Antibodypedia

 CHP1 antibodies

PROTEIN BROWSER
CHP1-001
CHP1-004
CHP1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHP1-001
ENSP00000335632
ENST00000334660
Q99653 [Direct mapping]
Calcineurin B homologous protein 1
A0A024R9M9 [Target identity:100%; Query identity:100%]
Calcium binding protein P22, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0001578 [microtubule bundle formation]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0004860 [protein kinase inhibitor activity]
GO:0005215 [transporter activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005975 [carbohydrate metabolic process]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006611 [protein export from nucleus]
GO:0006813 [potassium ion transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0010923 [negative regulation of phosphatase activity]
GO:0015459 [potassium channel regulator activity]
GO:0015630 [microtubule cytoskeleton]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0019900 [kinase binding]
GO:0022406 [membrane docking]
GO:0030133 [transport vesicle]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031953 [negative regulation of protein autophosphorylation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032417 [positive regulation of sodium:proton antiporter activity]
GO:0042308 [negative regulation of protein import into nucleus]
GO:0044281 [small molecule metabolic process]
GO:0048306 [calcium-dependent protein binding]
GO:0050821 [protein stabilization]
GO:0051222 [positive regulation of protein transport]
GO:0051259 [protein oligomerization]
GO:0051453 [regulation of intracellular pH]
GO:0060050 [positive regulation of protein glycosylation]
GO:0061024 [membrane organization]
GO:0061025 [membrane fusion]
GO:0070062 [extracellular exosome]
GO:0070885 [negative regulation of calcineurin-NFAT signaling cascade]
GO:0071468 [cellular response to acidic pH]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:1901214 [regulation of neuron death]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
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 195 aa
22.5 kDa 		No 0
CHP1-004
ENSP00000453392
ENST00000560965
H0YLY7 [Direct mapping]
Calcineurin B homologous protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 91 aa
10.6 kDa 		No 0
CHP1-006
ENSP00000454007
ENST00000560397
H0YNG9 [Direct mapping]
Calcineurin B homologous protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 154 aa
18 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.