Expression of ISG15 in cancer - Summary

CANCER ATLAS

Gene description

ISG15 ubiquitin-like modifier

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA004627

GENE INFORMATION
Gene name	ISG15 (HGNC Symbol)
Synonyms	G1P2, IFI15, UCRP
Description	ISG15 ubiquitin-like modifier (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	1001138 - 1014541
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187608 (version 83.38)
Entrez gene	9636
UniProt	P05161 (UniProt - Evidence at protein level)
neXtProt	NX_P05161
Antibodypedia	ISG15 antibodies

PROTEIN BROWSER

ISG15-001	ISG15-002	ISG15-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ISG15-001 ENSP00000368699 ENST00000379389	P05161 [Direct mapping] Ubiquitin-like protein ISG15 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0019941 [modification-dependent protein catabolic process] GO:0019985 [translesion synthesis] GO:0031386 [protein tag] GO:0031397 [negative regulation of protein ubiquitination] GO:0032020 [ISG15-protein conjugation] GO:0032480 [negative regulation of type I interferon production] GO:0032649 [regulation of interferon-gamma production] GO:0034340 [response to type I interferon] GO:0042742 [defense response to bacterium] GO:0045071 [negative regulation of viral genome replication] GO:0045087 [innate immune response] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0051607 [defense response to virus] GO:0060337 [type I interferon signaling pathway] Show all	165 aa 17.9 kDa	No	0
ISG15-002 ENSP00000485643 ENST00000624697	A0A096LPJ4 [Direct mapping] Ubiquitin-like protein ISG15 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	157 aa 17 kDa	No	0
ISG15-003 ENSP00000485313 ENST00000624652	A0A096LNZ9 [Direct mapping] Ubiquitin-like protein ISG15 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	144 aa 15.7 kDa	No	0