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ISG15

GENERAL INFORMATION

Gene name

 ISG15

Gene description

 ISG15 ubiquitin-like modifier

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA004627
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ISG15 (HGNC Symbol)

Synonyms

 G1P2, IFI15, UCRP

Description

 ISG15 ubiquitin-like modifier (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]

Chromosome

 1

Cytoband

 p36.33

Chromosome location (bp)

 1001138 - 1014541

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187608 (version 83.38)

Entrez gene

 9636

UniProt

 P05161 (UniProt - Evidence at protein level)

neXtProt

 NX_P05161

Antibodypedia

 ISG15 antibodies

PROTEIN BROWSER
ISG15-001
ISG15-002
ISG15-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ISG15-001
ENSP00000368699
ENST00000379389
P05161 [Direct mapping]
Ubiquitin-like protein ISG15
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019941 [modification-dependent protein catabolic process]
GO:0019985 [translesion synthesis]
GO:0031386 [protein tag]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0032020 [ISG15-protein conjugation]
GO:0032480 [negative regulation of type I interferon production]
GO:0032649 [regulation of interferon-gamma production]
GO:0034340 [response to type I interferon]
GO:0042742 [defense response to bacterium]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
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 165 aa
17.9 kDa 		No 0
ISG15-002
ENSP00000485643
ENST00000624697
A0A096LPJ4 [Direct mapping]
Ubiquitin-like protein ISG15
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 157 aa
17 kDa 		No 0
ISG15-003
ENSP00000485313
ENST00000624652
A0A096LNZ9 [Direct mapping]
Ubiquitin-like protein ISG15
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 144 aa
15.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.