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LAMTOR4

GENERAL INFORMATION

Gene name

 LAMTOR4

Gene description

 Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with a granular, lysosomal pattern in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA020998
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 LAMTOR4 (HGNC Symbol)

Synonyms

 C7orf59

Description

 Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100148907 - 100155944

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188186 (version 83.38)

Entrez gene

 389541

UniProt

 Q0VGL1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q0VGL1

Antibodypedia

 LAMTOR4 antibodies

PROTEIN BROWSER
LAMTOR4-001
LAMTOR4-002
LAMTOR4-003
LAMTOR4-005
LAMTOR4-007
LAMTOR4-008
LAMTOR4-009
LAMTOR4-011
LAMTOR4-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LAMTOR4-001
ENSP00000343118
ENST00000341942
Q0VGL1 [Direct mapping]
Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR4, N-terminally processed
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0008286 [insulin receptor signaling pathway]
GO:0008361 [regulation of cell size]
GO:0010467 [gene expression]
GO:0016236 [macroautophagy]
GO:0032008 [positive regulation of TOR signaling]
GO:0032947 [protein complex scaffold]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0061462 [protein localization to lysosome]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071986 [Ragulator complex]
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 99 aa
10.7 kDa 		No 0
LAMTOR4-002
ENSP00000477680
ENST00000474141
A0A087WT92 [Direct mapping]
Ragulator complex protein LAMTOR4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 72 aa
7.9 kDa 		No 0
LAMTOR4-003
ENSP00000479176
ENST00000460732
A0A087WV46 [Direct mapping]
Ragulator complex protein LAMTOR4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 82 aa
8.9 kDa 		No 0
LAMTOR4-005
ENSP00000387926
ENST00000441173
C9JXA7 [Direct mapping]
Ragulator complex protein LAMTOR4
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   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 137 aa
14.3 kDa 		No 0
LAMTOR4-007
ENSP00000478095
ENST00000468582
A0A087WVU0 [Direct mapping]
Ragulator complex protein LAMTOR4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 41 aa
4.7 kDa 		No 0
LAMTOR4-008
ENSP00000479500
ENST00000488241
A0A087WVK8 [Direct mapping]
Ragulator complex protein LAMTOR4
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 24 aa
2.8 kDa 		No 0
LAMTOR4-009
ENSP00000479685
ENST00000473459
A0A087WVU0 [Direct mapping]
Ragulator complex protein LAMTOR4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 41 aa
4.7 kDa 		No 0
LAMTOR4-011
ENSP00000480432
ENST00000466498
A0A087WWR0 [Direct mapping]
Ragulator complex protein LAMTOR4
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 20 aa
2.3 kDa 		No 0
LAMTOR4-012
ENSP00000481202
ENST00000490633
A0A087WXQ3 [Direct mapping]
Ragulator complex protein LAMTOR4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 19 aa
2.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.