Expression of PDCD1 in cancer - Summary

CANCER ATLAS

Gene description

Programmed cell death 1

Protein class

CD markers, Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035981	CAB038418

GENE INFORMATION
Gene name	PDCD1 (HGNC Symbol)
Synonyms	CD279, hSLE1, PD-1, PD1, SLEB2
Description	Programmed cell death 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q37.3
Chromosome location (bp)	241849881 - 241858908
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188389 (version 83.38)
Entrez gene	5133
UniProt	Q15116 (UniProt - Evidence at protein level)
neXtProt	NX_Q15116
Antibodypedia	PDCD1 antibodies

PROTEIN BROWSER

PDCD1-001	PDCD1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDCD1-001 ENSP00000335062 ENST00000334409	Q15116 [Direct mapping] Programmed cell death protein 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0002644 [negative regulation of tolerance induction] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006959 [humoral immune response] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0031295 [T cell costimulation] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0070234 [positive regulation of T cell apoptotic process] Show all	288 aa 31.6 kDa	No	1
PDCD1-003 ENSP00000340808 ENST00000343705	H0Y2W6 [Direct mapping] Programmed cell death protein 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	123 aa 13.8 kDa	No	0