Expression of INSC in cancer - Summary - The Human Protein Atlas

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INSC

TISSUE

CELL

CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

CANCER ATLAS

Gene description

Inscuteable homolog (Drosophila)

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039769

GENE INFORMATION
Gene name	INSC
Synonyms
Description	Inscuteable homolog (Drosophila) (HGNC Symbol)
Entrez gene summary	In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]
Chromosome	11
Cytoband	p15.2
Chromosome location (bp)	15112424 - 15247208
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188487 (version 83.38)
Entrez gene	387755
UniProt	Q1MX18 (UniProt - Evidence at protein level)
neXtProt	NX_Q1MX18
Antibodypedia	INSC antibodies

PROTEIN BROWSER

INSC-001	INSC-002	INSC-003	INSC-004	INSC-006	INSC-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INSC-001 ENSP00000368872 ENST00000379554	Q1MX18 [Direct mapping] Protein inscuteable homolog Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0000132 [establishment of mitotic spindle orientation] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] GO:0045177 [apical part of cell] GO:0060487 [lung epithelial cell differentiation] Show all	579 aa 63.5 kDa	No	0
INSC-002 ENSP00000368874 ENST00000379556	Q1MX18 [Direct mapping] Protein inscuteable homolog Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] Show all	532 aa 58.5 kDa	No	0
INSC-003 ENSP00000436194 ENST00000530161	Q1MX18 [Direct mapping] Protein inscuteable homolog Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] Show all	532 aa 58.5 kDa	No	0
INSC-004 ENSP00000436113 ENST00000525218	Q1MX18 [Direct mapping] Protein inscuteable homolog Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] Show all	490 aa 53.8 kDa	No	0
INSC-006 ENSP00000435022 ENST00000528567	Q1MX18 [Direct mapping] Protein inscuteable homolog Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] Show all	520 aa 57.2 kDa	No	0
INSC-201 ENSP00000389161 ENST00000424273	A0A0A0MSI1 [Direct mapping] Protein inscuteable homolog Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0005515 [protein binding] Show all	566 aa 61.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.