Tissue expression of INSC - Summary - The Human Protein Atlas

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INSC

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	INSC
Gene description	Inscuteable homolog (Drosophila)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (colon)
FANTOM5:	Tissue enhanced (retina)

Protein evidence

Evidence at protein level

Protein expression

Mainly cytoplasmic expression in gastrointestinal tract.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA039769
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (retina)

GENE INFORMATION
Gene name	INSC
Synonyms
Description	Inscuteable homolog (Drosophila) (HGNC Symbol)
Entrez gene summary	In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]
Chromosome	11
Cytoband	p15.2
Chromosome location (bp)	15112424 - 15247208
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188487 (version 83.38)
Entrez gene	387755
UniProt	Q1MX18 (UniProt - Evidence at protein level)
neXtProt	NX_Q1MX18
Antibodypedia	INSC antibodies

PROTEIN BROWSER

INSC-001	INSC-002	INSC-003	INSC-004	INSC-006	INSC-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INSC-001 ENSP00000368872 ENST00000379554	Q1MX18 [Direct mapping] Protein inscuteable homolog Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0000132 [establishment of mitotic spindle orientation] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] GO:0045177 [apical part of cell] GO:0060487 [lung epithelial cell differentiation] Show all	579 aa 63.5 kDa	No	0
INSC-002 ENSP00000368874 ENST00000379556	Q1MX18 [Direct mapping] Protein inscuteable homolog Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] Show all	532 aa 58.5 kDa	No	0
INSC-003 ENSP00000436194 ENST00000530161	Q1MX18 [Direct mapping] Protein inscuteable homolog Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] Show all	532 aa 58.5 kDa	No	0
INSC-004 ENSP00000436113 ENST00000525218	Q1MX18 [Direct mapping] Protein inscuteable homolog Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] Show all	490 aa 53.8 kDa	No	0
INSC-006 ENSP00000435022 ENST00000528567	Q1MX18 [Direct mapping] Protein inscuteable homolog Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] Show all	520 aa 57.2 kDa	No	0
INSC-201 ENSP00000389161 ENST00000424273	A0A0A0MSI1 [Direct mapping] Protein inscuteable homolog Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005488 [binding] GO:0005515 [protein binding] Show all	566 aa 61.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.