Fields »
ABOUT
HELP
BLOG
SRSF10

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 SRSF10

Gene description

 Serine/arginine-rich splicing factor 10

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA053831
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA053831 A-431 Nucleoplasm
HPA053831 HEK 293 Nucleoplasm
HPA053831 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 SRSF10 (HGNC Symbol)

Synonyms

 FUSIP1, FUSIP2, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR1, TASR2

Description

 Serine/arginine-rich splicing factor 10 (HGNC Symbol)

Entrez gene summary

 This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 23964804 - 23980927

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188529 (version 83.38)

Entrez gene

 10772

UniProt

 O75494 (UniProt - Evidence at protein level)

neXtProt

 NX_O75494

Antibodypedia

 SRSF10 antibodies

PROTEIN BROWSER
SRSF10-001
SRSF10-002
SRSF10-003
SRSF10-005
SRSF10-006
SRSF10-014
SRSF10-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRSF10-001
ENSP00000420195
ENST00000492112
O75494 [Direct mapping]
Serine/arginine-rich splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006376 [mRNA splice site selection]
GO:0006406 [mRNA export from nucleus]
GO:0016482 [cytoplasmic transport]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0050733 [RS domain binding]
GO:0051082 [unfolded protein binding]
Show all
 262 aa
31.3 kDa 		No 0
SRSF10-002
ENSP00000342913
ENST00000344989
O75494 [Direct mapping]
Serine/arginine-rich splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006376 [mRNA splice site selection]
GO:0006406 [mRNA export from nucleus]
GO:0016482 [cytoplasmic transport]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0050733 [RS domain binding]
GO:0051082 [unfolded protein binding]
Show all
 183 aa
22.2 kDa 		No 0
SRSF10-003
ENSP00000344149
ENST00000343255
O75494 [Direct mapping]
Serine/arginine-rich splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006376 [mRNA splice site selection]
GO:0006406 [mRNA export from nucleus]
GO:0016482 [cytoplasmic transport]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0050733 [RS domain binding]
GO:0051082 [unfolded protein binding]
Show all
 261 aa
31.2 kDa 		No 0
SRSF10-005
ENSP00000388991
ENST00000453840
O75494 [Direct mapping]
Serine/arginine-rich splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006376 [mRNA splice site selection]
GO:0006406 [mRNA export from nucleus]
GO:0016482 [cytoplasmic transport]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0050733 [RS domain binding]
GO:0051082 [unfolded protein binding]
Show all
 182 aa
22.1 kDa 		No 0
SRSF10-006
ENSP00000363576
ENST00000374452
O75494 [Direct mapping]
Serine/arginine-rich splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006376 [mRNA splice site selection]
GO:0006406 [mRNA export from nucleus]
GO:0016482 [cytoplasmic transport]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0050733 [RS domain binding]
GO:0051082 [unfolded protein binding]
Show all
 173 aa
21 kDa 		No 0
SRSF10-014
ENSP00000363577
ENST00000374453
Q5JRI1 [Direct mapping]
Serine/arginine-rich-splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 172 aa
20.9 kDa 		No 0
SRSF10-017
ENSP00000419813
ENST00000484146
O75494 [Direct mapping]
Serine/arginine-rich splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006376 [mRNA splice site selection]
GO:0006406 [mRNA export from nucleus]
GO:0016482 [cytoplasmic transport]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0050733 [RS domain binding]
GO:0051082 [unfolded protein binding]
Show all
 165 aa
20.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.