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SRSF10

GENERAL INFORMATION

Gene name

 SRSF10

Gene description

 Serine/arginine-rich splicing factor 10

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA053805 , HPA053831
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SRSF10 (HGNC Symbol)

Synonyms

 FUSIP1, FUSIP2, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR1, TASR2

Description

 Serine/arginine-rich splicing factor 10 (HGNC Symbol)

Entrez gene summary

 This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 23964804 - 23980927

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188529 (version 83.38)

Entrez gene

 10772

UniProt

 O75494 (UniProt - Evidence at protein level)

neXtProt

 NX_O75494

Antibodypedia

 SRSF10 antibodies

PROTEIN BROWSER
SRSF10-001
SRSF10-002
SRSF10-003
SRSF10-005
SRSF10-006
SRSF10-014
SRSF10-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRSF10-001
ENSP00000420195
ENST00000492112
O75494 [Direct mapping]
Serine/arginine-rich splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006376 [mRNA splice site selection]
GO:0006406 [mRNA export from nucleus]
GO:0016482 [cytoplasmic transport]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0050733 [RS domain binding]
GO:0051082 [unfolded protein binding]
Show all
 262 aa
31.3 kDa 		No 0
SRSF10-002
ENSP00000342913
ENST00000344989
O75494 [Direct mapping]
Serine/arginine-rich splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006376 [mRNA splice site selection]
GO:0006406 [mRNA export from nucleus]
GO:0016482 [cytoplasmic transport]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0050733 [RS domain binding]
GO:0051082 [unfolded protein binding]
Show all
 183 aa
22.2 kDa 		No 0
SRSF10-003
ENSP00000344149
ENST00000343255
O75494 [Direct mapping]
Serine/arginine-rich splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006376 [mRNA splice site selection]
GO:0006406 [mRNA export from nucleus]
GO:0016482 [cytoplasmic transport]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0050733 [RS domain binding]
GO:0051082 [unfolded protein binding]
Show all
 261 aa
31.2 kDa 		No 0
SRSF10-005
ENSP00000388991
ENST00000453840
O75494 [Direct mapping]
Serine/arginine-rich splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006376 [mRNA splice site selection]
GO:0006406 [mRNA export from nucleus]
GO:0016482 [cytoplasmic transport]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0050733 [RS domain binding]
GO:0051082 [unfolded protein binding]
Show all
 182 aa
22.1 kDa 		No 0
SRSF10-006
ENSP00000363576
ENST00000374452
O75494 [Direct mapping]
Serine/arginine-rich splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006376 [mRNA splice site selection]
GO:0006406 [mRNA export from nucleus]
GO:0016482 [cytoplasmic transport]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0050733 [RS domain binding]
GO:0051082 [unfolded protein binding]
Show all
 173 aa
21 kDa 		No 0
SRSF10-014
ENSP00000363577
ENST00000374453
Q5JRI1 [Direct mapping]
Serine/arginine-rich-splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 172 aa
20.9 kDa 		No 0
SRSF10-017
ENSP00000419813
ENST00000484146
O75494 [Direct mapping]
Serine/arginine-rich splicing factor 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006376 [mRNA splice site selection]
GO:0006406 [mRNA export from nucleus]
GO:0016482 [cytoplasmic transport]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0050733 [RS domain binding]
GO:0051082 [unfolded protein binding]
Show all
 165 aa
20.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.