Fields »
ABOUT
HELP
BLOG
HBA2

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 HBA2

Gene description

 Hemoglobin, alpha 2

Protein class

 Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (HEL, K-562)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HEL, K-562)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 HBA2 (HGNC Symbol)

Synonyms

 HBA-T2

Description

 Hemoglobin, alpha 2 (HGNC Symbol)

Entrez gene summary

 The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 172847 - 173710

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188536 (version 83.38)

Entrez gene

 3040

UniProt

 P69905 (UniProt - Evidence at protein level)

neXtProt

 NX_P69905

Antibodypedia

 HBA2 antibodies

PROTEIN BROWSER
HBA2-001
HBA2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HBA2-001
ENSP00000251595
ENST00000251595
P69905 [Direct mapping]
Hemoglobin subunit alpha
D1MGQ2 [Target identity:100%; Query identity:100%]
Alpha-2 globin chain; Delta globin; HCG1745306, isoform CRA_b
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004601 [peroxidase activity]
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005833 [hemoglobin complex]
GO:0006898 [receptor-mediated endocytosis]
GO:0010942 [positive regulation of cell death]
GO:0015671 [oxygen transport]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0031720 [haptoglobin binding]
GO:0031838 [haptoglobin-hemoglobin complex]
GO:0042542 [response to hydrogen peroxide]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051291 [protein heterooligomerization]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071682 [endocytic vesicle lumen]
GO:0072562 [blood microparticle]
Show all
 142 aa
15.3 kDa 		No 0
HBA2-002
ENSP00000380908
ENST00000397806
G3V1N2 [Direct mapping]
HCG1745306, isoform CRA_a; Hemoglobin subunit alpha
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005833 [hemoglobin complex]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
Show all
 110 aa
11.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.