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HBA2

GENERAL INFORMATION

Gene name

 HBA2

Gene description

 Hemoglobin, alpha 2

Protein class

 Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (bone marrow, placenta)
GTEx:Expressed in all
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in bone marrow with distinct positivity in erythrocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA043780 , CAB038417
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (bone marrow, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 HBA2 (HGNC Symbol)

Synonyms

 HBA-T2

Description

 Hemoglobin, alpha 2 (HGNC Symbol)

Entrez gene summary

 The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 172847 - 173710

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188536 (version 83.38)

Entrez gene

 3040

UniProt

 P69905 (UniProt - Evidence at protein level)

neXtProt

 NX_P69905

Antibodypedia

 HBA2 antibodies

PROTEIN BROWSER
HBA2-001
HBA2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HBA2-001
ENSP00000251595
ENST00000251595
P69905 [Direct mapping]
Hemoglobin subunit alpha
D1MGQ2 [Target identity:100%; Query identity:100%]
Alpha-2 globin chain; Delta globin; HCG1745306, isoform CRA_b
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004601 [peroxidase activity]
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005833 [hemoglobin complex]
GO:0006898 [receptor-mediated endocytosis]
GO:0010942 [positive regulation of cell death]
GO:0015671 [oxygen transport]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0031720 [haptoglobin binding]
GO:0031838 [haptoglobin-hemoglobin complex]
GO:0042542 [response to hydrogen peroxide]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051291 [protein heterooligomerization]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071682 [endocytic vesicle lumen]
GO:0072562 [blood microparticle]
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 142 aa
15.3 kDa 		No 0
HBA2-002
ENSP00000380908
ENST00000397806
G3V1N2 [Direct mapping]
HCG1745306, isoform CRA_a; Hemoglobin subunit alpha
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005833 [hemoglobin complex]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
Show all
 110 aa
11.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.