Expression of DPYD in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Dihydropyrimidine dehydrogenase

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA045210	CAB033241

GENE INFORMATION
Gene name	DPYD (HGNC Symbol)
Synonyms	DPD
Description	Dihydropyrimidine dehydrogenase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Chromosome	1
Cytoband	p21.3
Chromosome location (bp)	97077743 - 97921049
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188641 (version 83.38)
Entrez gene	1806
UniProt	Q12882 (UniProt - Evidence at protein level)
neXtProt	NX_Q12882
Antibodypedia	DPYD antibodies

PROTEIN BROWSER

DPYD-001	DPYD-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPYD-001 ENSP00000359211 ENST00000370192	Q12882 [Direct mapping] Dihydropyrimidine dehydrogenase [NADP(+)] Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006145 [purine nucleobase catabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006208 [pyrimidine nucleobase catabolic process] GO:0006210 [thymine catabolic process] GO:0006212 [uracil catabolic process] GO:0006214 [thymidine catabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0017113 [dihydropyrimidine dehydrogenase (NADP+) activity] GO:0019483 [beta-alanine biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0046135 [pyrimidine nucleoside catabolic process] GO:0046872 [metal ion binding] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	1025 aa 111.4 kDa	No	0
DPYD-002 ENSP00000307107 ENST00000306031	Q12882 [Direct mapping] Dihydropyrimidine dehydrogenase [NADP(+)] Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006145 [purine nucleobase catabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006208 [pyrimidine nucleobase catabolic process] GO:0006210 [thymine catabolic process] GO:0006212 [uracil catabolic process] GO:0006214 [thymidine catabolic process] GO:0017113 [dihydropyrimidine dehydrogenase (NADP+) activity] GO:0019483 [beta-alanine biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0046135 [pyrimidine nucleoside catabolic process] GO:0046872 [metal ion binding] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	173 aa 18.9 kDa	No	0