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DPYD

GENERAL INFORMATION

Gene name

 DPYD

Gene description

 Dihydropyrimidine dehydrogenase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in immune cells in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA045210 , CAB033241
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DPYD (HGNC Symbol)

Synonyms

 DPD

Description

 Dihydropyrimidine dehydrogenase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Chromosome

 1

Cytoband

 p21.3

Chromosome location (bp)

 97077743 - 97921049

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188641 (version 83.38)

Entrez gene

 1806

UniProt

 Q12882 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12882

Antibodypedia

 DPYD antibodies

PROTEIN BROWSER
DPYD-001
DPYD-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DPYD-001
ENSP00000359211
ENST00000370192
Q12882 [Direct mapping]
Dihydropyrimidine dehydrogenase [NADP(+)]
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006145 [purine nucleobase catabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006208 [pyrimidine nucleobase catabolic process]
GO:0006210 [thymine catabolic process]
GO:0006212 [uracil catabolic process]
GO:0006214 [thymidine catabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0017113 [dihydropyrimidine dehydrogenase (NADP+) activity]
GO:0019483 [beta-alanine biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046135 [pyrimidine nucleoside catabolic process]
GO:0046872 [metal ion binding]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 1025 aa
111.4 kDa 		No 0
DPYD-002
ENSP00000307107
ENST00000306031
Q12882 [Direct mapping]
Dihydropyrimidine dehydrogenase [NADP(+)]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006145 [purine nucleobase catabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006208 [pyrimidine nucleobase catabolic process]
GO:0006210 [thymine catabolic process]
GO:0006212 [uracil catabolic process]
GO:0006214 [thymidine catabolic process]
GO:0017113 [dihydropyrimidine dehydrogenase (NADP+) activity]
GO:0019483 [beta-alanine biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046135 [pyrimidine nucleoside catabolic process]
GO:0046872 [metal ion binding]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 173 aa
18.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.