Expression of UROS in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Uroporphyrinogen III synthase

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA044038

GENE INFORMATION
Gene name	UROS
Synonyms
Description	Uroporphyrinogen III synthase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q26.2
Chromosome location (bp)	125784980 - 125823248
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188690 (version 83.38)
Entrez gene	7390
UniProt	P10746 (UniProt - Evidence at protein level)
neXtProt	NX_P10746
Antibodypedia	UROS antibodies

PROTEIN BROWSER

UROS-001	UROS-002	UROS-003	UROS-004	UROS-006	UROS-007	UROS-012	UROS-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UROS-001 ENSP00000357787 ENST00000368797	P10746 [Direct mapping] Uroporphyrinogen-III synthase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004852 [uroporphyrinogen-III synthase activity] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006778 [porphyrin-containing compound metabolic process] GO:0006779 [porphyrin-containing compound biosynthetic process] GO:0006780 [uroporphyrinogen III biosynthetic process] GO:0006782 [protoporphyrinogen IX biosynthetic process] GO:0006783 [heme biosynthetic process] GO:0033014 [tetrapyrrole biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046677 [response to antibiotic] GO:0048037 [cofactor binding] GO:0071243 [cellular response to arsenic-containing substance] GO:0071418 [cellular response to amine stimulus] Show all	265 aa 28.6 kDa	No	0
UROS-002 ENSP00000357775 ENST00000368786	P10746 [Direct mapping] Uroporphyrinogen-III synthase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004852 [uroporphyrinogen-III synthase activity] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006778 [porphyrin-containing compound metabolic process] GO:0006780 [uroporphyrinogen III biosynthetic process] GO:0006782 [protoporphyrinogen IX biosynthetic process] GO:0006783 [heme biosynthetic process] GO:0033014 [tetrapyrrole biosynthetic process] GO:0044281 [small molecule metabolic process] Show all	265 aa 28.6 kDa	No	0
UROS-003 ENSP00000357767 ENST00000368778	Q5T3L8 [Direct mapping] Uroporphyrinogen III synthase (Congenital erythropoietic porphyria), isoform CRA_c; Uroporphyrinogen-III synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004852 [uroporphyrinogen-III synthase activity] GO:0033014 [tetrapyrrole biosynthetic process] Show all	139 aa 15.4 kDa	No	0
UROS-004 ENSP00000414833 ENST00000420761	Q5T3L9 [Direct mapping] Uroporphyrinogen-III synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004852 [uroporphyrinogen-III synthase activity] GO:0033014 [tetrapyrrole biosynthetic process] Show all	185 aa 20.3 kDa	No	0
UROS-006 ENSP00000357763 ENST00000368774	Q5T3L7 [Direct mapping] Uroporphyrinogen-III synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004852 [uroporphyrinogen-III synthase activity] GO:0033014 [tetrapyrrole biosynthetic process] Show all	133 aa 14.7 kDa	No	0
UROS-007 ENSP00000478957 ENST00000462490	A0A087WUV7 [Direct mapping] Uroporphyrinogen-III synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004852 [uroporphyrinogen-III synthase activity] GO:0033014 [tetrapyrrole biosynthetic process] Show all	110 aa 11.9 kDa	No	0
UROS-012 ENSP00000482520 ENST00000616800	A0A087WZB7 [Direct mapping] Uroporphyrinogen-III synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004852 [uroporphyrinogen-III synthase activity] GO:0033014 [tetrapyrrole biosynthetic process] Show all	68 aa 7.5 kDa	No	0
UROS-013 ENSP00000483041 ENST00000622016	A0A087X021 [Direct mapping] Uroporphyrinogen-III synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004852 [uroporphyrinogen-III synthase activity] GO:0033014 [tetrapyrrole biosynthetic process] Show all	122 aa 13.5 kDa	No	0