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UROS

GENERAL INFORMATION

Gene name

 UROS

Gene description

 Uroporphyrinogen III synthase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044038
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UROS

Synonyms

Description

 Uroporphyrinogen III synthase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q26.2

Chromosome location (bp)

 125784980 - 125823248

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188690 (version 83.38)

Entrez gene

 7390

UniProt

 P10746 (UniProt - Evidence at protein level)

neXtProt

 NX_P10746

Antibodypedia

 UROS antibodies

PROTEIN BROWSER
UROS-001
UROS-002
UROS-003
UROS-004
UROS-006
UROS-007
UROS-012
UROS-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UROS-001
ENSP00000357787
ENST00000368797
P10746 [Direct mapping]
Uroporphyrinogen-III synthase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004852 [uroporphyrinogen-III synthase activity]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0006779 [porphyrin-containing compound biosynthetic process]
GO:0006780 [uroporphyrinogen III biosynthetic process]
GO:0006782 [protoporphyrinogen IX biosynthetic process]
GO:0006783 [heme biosynthetic process]
GO:0033014 [tetrapyrrole biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046677 [response to antibiotic]
GO:0048037 [cofactor binding]
GO:0071243 [cellular response to arsenic-containing substance]
GO:0071418 [cellular response to amine stimulus]
Show all
 265 aa
28.6 kDa 		No 0
UROS-002
ENSP00000357775
ENST00000368786
P10746 [Direct mapping]
Uroporphyrinogen-III synthase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004852 [uroporphyrinogen-III synthase activity]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0006780 [uroporphyrinogen III biosynthetic process]
GO:0006782 [protoporphyrinogen IX biosynthetic process]
GO:0006783 [heme biosynthetic process]
GO:0033014 [tetrapyrrole biosynthetic process]
GO:0044281 [small molecule metabolic process]
Show all
 265 aa
28.6 kDa 		No 0
UROS-003
ENSP00000357767
ENST00000368778
Q5T3L8 [Direct mapping]
Uroporphyrinogen III synthase (Congenital erythropoietic porphyria), isoform CRA_c; Uroporphyrinogen-III synthase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004852 [uroporphyrinogen-III synthase activity]
GO:0033014 [tetrapyrrole biosynthetic process]
Show all
 139 aa
15.4 kDa 		No 0
UROS-004
ENSP00000414833
ENST00000420761
Q5T3L9 [Direct mapping]
Uroporphyrinogen-III synthase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004852 [uroporphyrinogen-III synthase activity]
GO:0033014 [tetrapyrrole biosynthetic process]
Show all
 185 aa
20.3 kDa 		No 0
UROS-006
ENSP00000357763
ENST00000368774
Q5T3L7 [Direct mapping]
Uroporphyrinogen-III synthase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004852 [uroporphyrinogen-III synthase activity]
GO:0033014 [tetrapyrrole biosynthetic process]
Show all
 133 aa
14.7 kDa 		No 0
UROS-007
ENSP00000478957
ENST00000462490
A0A087WUV7 [Direct mapping]
Uroporphyrinogen-III synthase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004852 [uroporphyrinogen-III synthase activity]
GO:0033014 [tetrapyrrole biosynthetic process]
Show all
 110 aa
11.9 kDa 		No 0
UROS-012
ENSP00000482520
ENST00000616800
A0A087WZB7 [Direct mapping]
Uroporphyrinogen-III synthase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004852 [uroporphyrinogen-III synthase activity]
GO:0033014 [tetrapyrrole biosynthetic process]
Show all
 68 aa
7.5 kDa 		No 0
UROS-013
ENSP00000483041
ENST00000622016
A0A087X021 [Direct mapping]
Uroporphyrinogen-III synthase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004852 [uroporphyrinogen-III synthase activity]
GO:0033014 [tetrapyrrole biosynthetic process]
Show all
 122 aa
13.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.