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LIPI

GENERAL INFORMATION

Gene name

 LIPI

Gene description

 Lipase, member I

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (epididymis)
GTEx:Tissue enhanced (thyroid gland)
FANTOM5:Tissue enriched (epididymis)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (epididymis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (epididymis)

GENE INFORMATION

Gene name

 LIPI (HGNC Symbol)

Synonyms

 CT17, LPDL, mPA-PLA1beta, PLA1C, PRED5

Description

 Lipase, member I (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Chromosome

 21

Cytoband

 q11.2

Chromosome location (bp)

 14108813 - 14210891

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188992 (version 83.38)

Entrez gene

 149998

UniProt

 Q6XZB0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6XZB0

Antibodypedia

 LIPI antibodies

PROTEIN BROWSER
LIPI-001
LIPI-002
LIPI-201
LIPI-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIPI-001
ENSP00000343331
ENST00000344577
Q6XZB0 [Direct mapping]
Lipase member I
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004620 [phospholipase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0008201 [heparin binding]
GO:0016020 [membrane]
GO:0016042 [lipid catabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
Show all
 481 aa
55.2 kDa 		No 0
LIPI-002
ENSP00000383072
ENST00000400211
H0Y3S0 [Direct mapping]
Lipase member I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0008152 [metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
Show all
 141 aa
15.7 kDa 		No 0
LIPI-201
ENSP00000440381
ENST00000536861
Q6XZB0 [Direct mapping]
Lipase member I
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004620 [phospholipase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0008201 [heparin binding]
GO:0016020 [membrane]
GO:0016042 [lipid catabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
Show all
 451 aa
51.8 kDa 		No 0
LIPI-202
ENSP00000482652
ENST00000614229
A0A087WZG8 [Direct mapping]
Lipase member I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0006629 [lipid metabolic process]
GO:0008152 [metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
Show all
 421 aa
48.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.