Tissue expression of IL1RAP - Summary - The Human Protein Atlas

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IL1RAP

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	IL1RAP
Gene description	Interleukin 1 receptor accessory protein
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (liver, placenta)
GTEx:	Tissue enhanced (liver)
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA035293
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	IL1RAP (HGNC Symbol)
Synonyms	C3orf13, IL-1RAcP, IL1R3
Description	Interleukin 1 receptor accessory protein (HGNC Symbol)
Entrez gene summary	Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]
Chromosome	3
Cytoband	q28
Chromosome location (bp)	190514051 - 190659750
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196083 (version 83.38)
Entrez gene	3556
UniProt	Q9NPH3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NPH3
Antibodypedia	IL1RAP antibodies

PROTEIN BROWSER

IL1RAP-001	IL1RAP-002	IL1RAP-003	IL1RAP-005	IL1RAP-006	IL1RAP-007	IL1RAP-008	IL1RAP-010	IL1RAP-016	IL1RAP-017	IL1RAP-201	IL1RAP-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL1RAP-001 ENSP00000072516 ENST00000072516	Q9NPH3 [Direct mapping] Interleukin-1 receptor accessory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0045087 [innate immune response] Show all	570 aa 65.4 kDa	Yes	1
IL1RAP-002 ENSP00000401132 ENST00000439062	Q9NPH3 [Direct mapping] Interleukin-1 receptor accessory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0045087 [innate immune response] Show all	570 aa 65.4 kDa	Yes	1
IL1RAP-003 ENSP00000409352 ENST00000422485	Q9NPH3 [Direct mapping] Interleukin-1 receptor accessory protein Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0016020 [membrane] GO:0045087 [innate immune response] Show all	356 aa 41 kDa	Yes	0
IL1RAP-005 ENSP00000390541 ENST00000447382	Q9NPH3 [Direct mapping] Interleukin-1 receptor accessory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0045087 [innate immune response] Show all	570 aa 65.4 kDa	Yes	1
IL1RAP-006 ENSP00000314807 ENST00000317757	Q9NPH3 [Direct mapping] Interleukin-1 receptor accessory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0004908 [interleukin-1 receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0042094 [interleukin-2 biosynthetic process] GO:0043234 [protein complex] GO:0045087 [innate immune response] Show all	687 aa 78.6 kDa	Yes	1
IL1RAP-007 ENSP00000391899 ENST00000434491	C9J9W1 [Direct mapping] Interleukin-1 receptor accessory protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004908 [interleukin-1 receptor activity] GO:0005515 [protein binding] GO:0019221 [cytokine-mediated signaling pathway] Show all	215 aa 24.3 kDa	No	0
IL1RAP-008 ENSP00000387371 ENST00000422940	Q9NPH3 [Direct mapping] Interleukin-1 receptor accessory protein Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0016020 [membrane] GO:0045087 [innate immune response] Show all	356 aa 41 kDa	Yes	0
IL1RAP-010 ENSP00000389149 ENST00000422625	C9JT28 [Direct mapping] Interleukin-1 receptor accessory protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		113 aa 13.5 kDa	Yes	0
IL1RAP-016 ENSP00000412008 ENST00000453359	C9J1D9 [Direct mapping] Interleukin-1 receptor accessory protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	145 aa 17.2 kDa	Yes	0
IL1RAP-017 ENSP00000414102 ENST00000412080	H7C3W4 [Direct mapping] Interleukin-1 receptor accessory protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004908 [interleukin-1 receptor activity] GO:0005515 [protein binding] GO:0019221 [cytokine-mediated signaling pathway] Show all	193 aa 21.6 kDa	No	0
IL1RAP-201 ENSP00000412053 ENST00000412504	Q9NPH3 [Direct mapping] Interleukin-1 receptor accessory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0045087 [innate immune response] Show all	570 aa 65.4 kDa	Yes	1
IL1RAP-202 ENSP00000408893 ENST00000443369	Q9NPH3 [Direct mapping] Interleukin-1 receptor accessory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0045087 [innate immune response] Show all	687 aa 78.6 kDa	Yes	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.