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MYT1

GENERAL INFORMATION

Gene name

 MYT1

Gene description

 Myelin transcription factor 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, adrenal gland)
GTEx:Tissue enriched (cerebellum)
FANTOM5:Tissue enriched (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in granular layer of cerebellum and cytoplasmic expression in several other tissues.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending retesting.

Reliability score

 Uncertain based on 1 antibody.
HPA006303
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)

GENE INFORMATION

Gene name

 MYT1 (HGNC Symbol)

Synonyms

 MTF1, MYTI, NZF2, PLPB1, ZC2HC4A

Description

 Myelin transcription factor 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 64151791 - 64242253

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196132 (version 83.38)

Entrez gene

 4661

UniProt

 Q01538 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01538

Antibodypedia

 MYT1 antibodies

PROTEIN BROWSER
MYT1-001
MYT1-002
MYT1-201
MYT1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYT1-001
ENSP00000327465
ENST00000328439
Q01538 [Direct mapping]
Myelin transcription factor 1
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001678 [cellular glucose homeostasis]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007399 [nervous system development]
GO:0008270 [zinc ion binding]
GO:0009791 [post-embryonic development]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0031018 [endocrine pancreas development]
GO:0032350 [regulation of hormone metabolic process]
GO:0060539 [diaphragm development]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
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 1121 aa
122.3 kDa 		No 0
MYT1-002
ENSP00000353269
ENST00000360149
Q6P6D5 [Direct mapping]
MYT1 protein; Myelin transcription factor 1
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Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
Show all
 591 aa
64.6 kDa 		No 0
MYT1-201
ENSP00000442412
ENST00000536311
Q01538 [Direct mapping]
Myelin transcription factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007399 [nervous system development]
GO:0008270 [zinc ion binding]
GO:0030154 [cell differentiation]
Show all
 1148 aa
125.1 kDa 		No 0
MYT1-202
ENSP00000480510
ENST00000622439
Q6P6D5 [Direct mapping]
MYT1 protein; Myelin transcription factor 1
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Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
Show all
 591 aa
64.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.