Cell atlas - CTSE - The Human Protein Atlas

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CTSE

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CTSE
Gene description	Cathepsin E
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (RT4, BEWO)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RT4, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CTSE
Synonyms
Description	Cathepsin E (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	206009264 - 206023909
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196188 (version 83.38)
Entrez gene	1510
UniProt	P14091 (UniProt - Evidence at protein level)
neXtProt	NX_P14091
Antibodypedia	CTSE antibodies

PROTEIN BROWSER

CTSE-001	CTSE-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTSE-001 ENSP00000350911 ENST00000358184	P14091 [Direct mapping] Cathepsin E Cathepsin E form I Cathepsin E form II Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005768 [endosome] GO:0006508 [proteolysis] GO:0007586 [digestion] GO:0016540 [protein autoprocessing] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030163 [protein catabolic process] GO:0042803 [protein homodimerization activity] GO:0070062 [extracellular exosome] Show all	396 aa 42.8 kDa	Yes	0
CTSE-002 ENSP00000353350 ENST00000360218	P14091 [Direct mapping] Cathepsin E Cathepsin E form I Cathepsin E form II Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005768 [endosome] GO:0006508 [proteolysis] GO:0007586 [digestion] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030163 [protein catabolic process] GO:0070062 [extracellular exosome] Show all	363 aa 39.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.