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CTSE

GENERAL INFORMATION

Gene name

 CTSE

Gene description

 Cathepsin E

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (stomach, duodenum)
GTEx:Tissue enriched (stomach)
FANTOM5:Group enriched (gallbladder, colon, small intestine, lung)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression most abundant in stomach but also in intestine, gallbladder, urinary bladder and squamous epithelia of tonsil.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA012940 , CAB032687
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (stomach, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (gallbladder, colon, small intestine, lung)

GENE INFORMATION

Gene name

 CTSE

Synonyms

Description

 Cathepsin E (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 206009264 - 206023909

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196188 (version 83.38)

Entrez gene

 1510

UniProt

 P14091 (UniProt - Evidence at protein level)

neXtProt

 NX_P14091

Antibodypedia

 CTSE antibodies

PROTEIN BROWSER
CTSE-001
CTSE-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTSE-001
ENSP00000350911
ENST00000358184
P14091 [Direct mapping]
Cathepsin E Cathepsin E form I Cathepsin E form II
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Aspartic-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005768 [endosome]
GO:0006508 [proteolysis]
GO:0007586 [digestion]
GO:0016540 [protein autoprocessing]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030163 [protein catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0070062 [extracellular exosome]
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 396 aa
42.8 kDa 		Yes 0
CTSE-002
ENSP00000353350
ENST00000360218
P14091 [Direct mapping]
Cathepsin E Cathepsin E form I Cathepsin E form II
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Aspartic-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005768 [endosome]
GO:0006508 [proteolysis]
GO:0007586 [digestion]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030163 [protein catabolic process]
GO:0070062 [extracellular exosome]
Show all
 363 aa
39.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.