Tissue expression of GREB1 - Summary - The Human Protein Atlas

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GREB1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GREB1
Gene description	Growth regulation by estrogen in breast cancer 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (ovary)
GTEx:	Tissue enhanced (ovary)
FANTOM5:	Tissue enhanced (ovary)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 3 antibodies. HPA024616 , HPA027843 , HPA028416
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (ovary)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (ovary)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (ovary)

GENE INFORMATION
Gene name	GREB1 (HGNC Symbol)
Synonyms	KIAA0575
Description	Growth regulation by estrogen in breast cancer 1 (HGNC Symbol)
Entrez gene summary	This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p25.1
Chromosome location (bp)	11482341 - 11642788
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196208 (version 83.38)
Entrez gene	9687
UniProt	Q4ZG55 (UniProt - Evidence at transcript level)
neXtProt	NX_Q4ZG55
Antibodypedia	GREB1 antibodies

PROTEIN BROWSER

GREB1-001	GREB1-002	GREB1-003	GREB1-004	GREB1-005	GREB1-006	GREB1-010	GREB1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GREB1-001 ENSP00000370896 ENST00000381486	Q4ZG55 [Direct mapping] Protein GREB1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	1949 aa 216.5 kDa	No	1
GREB1-002 ENSP00000263834 ENST00000263834	Q4ZG55 [Direct mapping] Protein GREB1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	409 aa 43.3 kDa	No	0
GREB1-003 ENSP00000374475 ENST00000389825	F8W6E5 [Direct mapping] Protein GREB1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		253 aa 26.3 kDa	No	0
GREB1-004 ENSP00000370892 ENST00000381483	Q4ZG55 [Direct mapping] Protein GREB1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	457 aa 48.9 kDa	No	0
GREB1-005 ENSP00000403886 ENST00000432985	C9JIG0 [Direct mapping] Protein GREB1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		541 aa 60.2 kDa	No	0
GREB1-006 ENSP00000379429 ENST00000396123	Q4ZG55 [Direct mapping] Protein GREB1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	947 aa 107.2 kDa	No	1
GREB1-010 ENSP00000487278 ENST00000628795	A0A0D9SG99 [Direct mapping] Protein GREB1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		79 aa 8.7 kDa	No	0
GREB1-201 ENSP00000234142 ENST00000234142	Q4ZG55 [Direct mapping] Protein GREB1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	1949 aa 216.5 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.