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A few cases of gliomas, skin, colorectal, ovarian and cervical cancers displayed moderate cytoplasmic and/or nuclear positivity. Remaining cancer tissues were weakly stained or negative.
Single case of non-Hodgkin's lymphoma displayed strong cytoplasmic staining. A few cases of gliomas, prostate, ovarian, endometrial, cervical, breast and thyroid cancers exhibited weak to moderate cytoplasmic positivity, with additional nuclear or membranous positivity in some cases. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
SRGAP3 (HGNC Symbol)
Synonyms
ARHGAP14, KIAA0411, MEGAP, SRGAP2, WRP
Description
SLIT-ROBO Rho GTPase activating protein 3 (HGNC Symbol)
O43295 [Direct mapping] SLIT-ROBO Rho GTPase-activating protein 3
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THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0030336 [negative regulation of cell migration] GO:0043547 [positive regulation of GTPase activity] GO:0048365 [Rac GTPase binding] GO:0051056 [regulation of small GTPase mediated signal transduction]
O43295 [Direct mapping] SLIT-ROBO Rho GTPase-activating protein 3
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0030336 [negative regulation of cell migration] GO:0043547 [positive regulation of GTPase activity] GO:0048365 [Rac GTPase binding] GO:0051056 [regulation of small GTPase mediated signal transduction]
A0A087WZH4 [Direct mapping] SLIT-ROBO Rho GTPase-activating protein 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
