Cell atlas - SRGAP3 - The Human Protein Atlas

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SRGAP3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SRGAP3
Gene description	SLIT-ROBO Rho GTPase activating protein 3
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Cell line enhanced (T-47d, AF22, RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA036959 , HPA044074
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, AF22, RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA036959	A-431	Nucleoplasm
HPA036959	A-431	Vesicles
HPA036959	RT4	Nucleoplasm
HPA036959	U-2 OS	Nucleoplasm
HPA044074	RT4	Nucleoplasm
HPA044074	U-2 OS	No staining
HPA044074	U-251 MG	No staining

GENE INFORMATION
Gene name	SRGAP3 (HGNC Symbol)
Synonyms	ARHGAP14, KIAA0411, MEGAP, SRGAP2, WRP
Description	SLIT-ROBO Rho GTPase activating protein 3 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	8980591 - 9363053
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196220 (version 83.38)
Entrez gene	9901
UniProt	O43295 (UniProt - Evidence at protein level)
neXtProt	NX_O43295
Antibodypedia	SRGAP3 antibodies

PROTEIN BROWSER

SRGAP3-001	SRGAP3-002	SRGAP3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SRGAP3-001 ENSP00000373347 ENST00000383836	O43295 [Direct mapping] SLIT-ROBO Rho GTPase-activating protein 3 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0030336 [negative regulation of cell migration] GO:0043547 [positive regulation of GTPase activity] GO:0048365 [Rac GTPase binding] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	1099 aa 124.5 kDa	No	0
SRGAP3-002 ENSP00000353587 ENST00000360413	O43295 [Direct mapping] SLIT-ROBO Rho GTPase-activating protein 3 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0030336 [negative regulation of cell migration] GO:0043547 [positive regulation of GTPase activity] GO:0048365 [Rac GTPase binding] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	1075 aa 121.8 kDa	No	0
SRGAP3-201 ENSP00000482666 ENST00000618999	A0A087WZH4 [Direct mapping] SLIT-ROBO Rho GTPase-activating protein 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005737 [cytoplasm] GO:0030336 [negative regulation of cell migration] GO:0043547 [positive regulation of GTPase activity] GO:0048365 [Rac GTPase binding] Show all	335 aa 38.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.