Cell atlas - ATP2A1 - The Human Protein Atlas

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ATP2A1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	ATP2A1
Gene description	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB002310
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB002310	A-431	Endoplasmic reticulum
	CAB002310	U-2 OS	Endoplasmic reticulum
	CAB002310	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	ATP2A1 (HGNC Symbol)
Synonyms	ATP2A, SERCA1
Description	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	28878405 - 28904509
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196296 (version 83.38)
Entrez gene	487
UniProt	O14983 (UniProt - Evidence at protein level)
neXtProt	NX_O14983
Antibodypedia	ATP2A1 antibodies

PROTEIN BROWSER

ATP2A1-001	ATP2A1-002	ATP2A1-003	ATP2A1-007	ATP2A1-008	ATP2A1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP2A1-001 ENSP00000349595 ENST00000357084	O14983 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005789 [endoplasmic reticulum membrane] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005887 [integral component of plasma membrane] GO:0006816 [calcium ion transport] GO:0006942 [regulation of striated muscle contraction] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0008637 [apoptotic mitochondrial changes] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0031448 [positive regulation of fast-twitch skeletal muscle fiber contraction] GO:0031673 [H zone] GO:0031674 [I band] GO:0032470 [positive regulation of endoplasmic reticulum calcium ion concentration] GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034220 [ion transmembrane transport] GO:0034704 [calcium channel complex] GO:0034976 [response to endoplasmic reticulum stress] GO:0042803 [protein homodimerization activity] GO:0045988 [negative regulation of striated muscle contraction] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0051659 [maintenance of mitochondrion location] GO:0055085 [transmembrane transport] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0090076 [relaxation of skeletal muscle] Show all	1001 aa 110.3 kDa	No	>9
ATP2A1-002 ENSP00000378879 ENST00000395503	O14983 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005789 [endoplasmic reticulum membrane] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005887 [integral component of plasma membrane] GO:0006816 [calcium ion transport] GO:0006942 [regulation of striated muscle contraction] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0008637 [apoptotic mitochondrial changes] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0031448 [positive regulation of fast-twitch skeletal muscle fiber contraction] GO:0031673 [H zone] GO:0031674 [I band] GO:0032470 [positive regulation of endoplasmic reticulum calcium ion concentration] GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034220 [ion transmembrane transport] GO:0034704 [calcium channel complex] GO:0034976 [response to endoplasmic reticulum stress] GO:0042803 [protein homodimerization activity] GO:0045988 [negative regulation of striated muscle contraction] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0051659 [maintenance of mitochondrion location] GO:0055085 [transmembrane transport] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0090076 [relaxation of skeletal muscle] Show all	994 aa 109.3 kDa	No	>9
ATP2A1-003 ENSP00000443101 ENST00000536376	O14983 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005789 [endoplasmic reticulum membrane] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005887 [integral component of plasma membrane] GO:0006816 [calcium ion transport] GO:0006942 [regulation of striated muscle contraction] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0008637 [apoptotic mitochondrial changes] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0031448 [positive regulation of fast-twitch skeletal muscle fiber contraction] GO:0031673 [H zone] GO:0031674 [I band] GO:0032470 [positive regulation of endoplasmic reticulum calcium ion concentration] GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034220 [ion transmembrane transport] GO:0034704 [calcium channel complex] GO:0034976 [response to endoplasmic reticulum stress] GO:0042803 [protein homodimerization activity] GO:0045988 [negative regulation of striated muscle contraction] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0051659 [maintenance of mitochondrion location] GO:0055085 [transmembrane transport] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0090076 [relaxation of skeletal muscle] Show all	869 aa 95.2 kDa	No	8
ATP2A1-007 ENSP00000458035 ENST00000563975	H3BVB2 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005524 [ATP binding] GO:0016021 [integral component of membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0046872 [metal ion binding] GO:0070588 [calcium ion transmembrane transport] Show all	114 aa 13.1 kDa	No	2
ATP2A1-008 ENSP00000457798 ENST00000562185	H3BUU3 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0046872 [metal ion binding] Show all	26 aa 3 kDa	No	0
ATP2A1-010 ENSP00000457793 ENST00000564112	H3BUT9 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		24 aa 2.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.