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Most cancer cells showed moderate to strong cytoplasmic positivity with additional nuclear staining in many cases. Several cases of renal cancers were negative.
Lymphomas exhibited strong cytoplasmic staining in most cases whereas melanomas, endometrial and cervical malignancies exhibited several strongly stained cases. Remaining cancers displayed occasional distinctly stained cases but most malignant cells were negative.
GENE INFORMATION
Gene name
PTPN1 (HGNC Symbol)
Synonyms
PTP1B
Description
Protein tyrosine phosphatase, non-receptor type 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]