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NOXO1

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GENERAL INFORMATION

Gene name

 NOXO1

Gene description

 NADPH oxidase organizer 1

Protein class

 FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (CAPAN-2, SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 NOXO1 (HGNC Symbol)

Synonyms

 P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28

Description

 NADPH oxidase organizer 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 1978917 - 1984192

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196408 (version 83.38)

Entrez gene

 124056

UniProt

 Q8NFA2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFA2

Antibodypedia

 NOXO1 antibodies

PROTEIN BROWSER
NOXO1-001
NOXO1-002
NOXO1-003
NOXO1-005
NOXO1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOXO1-001
ENSP00000346195
ENST00000354249
Q8NFA2 [Direct mapping]
NADPH oxidase organizer 1
Show all
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010310 [regulation of hydrogen peroxide metabolic process]
GO:0016176 [superoxide-generating NADPH oxidase activator activity]
GO:0019899 [enzyme binding]
GO:0022617 [extracellular matrix disassembly]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0043020 [NADPH oxidase complex]
GO:0060263 [regulation of respiratory burst]
Show all
 370 aa
40.7 kDa 		No 0
NOXO1-002
ENSP00000348435
ENST00000356120
Q8NFA2 [Direct mapping]
NADPH oxidase organizer 1
Show all
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010310 [regulation of hydrogen peroxide metabolic process]
GO:0016176 [superoxide-generating NADPH oxidase activator activity]
GO:0019899 [enzyme binding]
GO:0022617 [extracellular matrix disassembly]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0043020 [NADPH oxidase complex]
GO:0060263 [regulation of respiratory burst]
Show all
 371 aa
40.8 kDa 		No 0
NOXO1-003
ENSP00000380450
ENST00000397280
Q8NFA2 [Direct mapping]
NADPH oxidase organizer 1
Show all
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006801 [superoxide metabolic process]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010310 [regulation of hydrogen peroxide metabolic process]
GO:0016176 [superoxide-generating NADPH oxidase activator activity]
GO:0019899 [enzyme binding]
GO:0022617 [extracellular matrix disassembly]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0043020 [NADPH oxidase complex]
GO:0043085 [positive regulation of catalytic activity]
GO:0060263 [regulation of respiratory burst]
Show all
 376 aa
41.3 kDa 		No 0
NOXO1-005
ENSP00000456800
ENST00000566005
Q8NFA2 [Direct mapping]
NADPH oxidase organizer 1
Show all
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010310 [regulation of hydrogen peroxide metabolic process]
GO:0016176 [superoxide-generating NADPH oxidase activator activity]
GO:0019899 [enzyme binding]
GO:0022617 [extracellular matrix disassembly]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0043020 [NADPH oxidase complex]
GO:0060263 [regulation of respiratory burst]
Show all
 375 aa
41.1 kDa 		No 0
NOXO1-006
ENSP00000454644
ENST00000567471
H3BN18 [Direct mapping]
NADPH oxidase organizer 1
Show all
Predicted intracellular proteins
Show all
GO:0035091 [phosphatidylinositol binding]
Show all
 76 aa
8.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.