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NOXO1

GENERAL INFORMATION

Gene name

 NOXO1

Gene description

 NADPH oxidase organizer 1

Protein class

 FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (colon, rectum, appendix)
GTEx:Mixed
FANTOM5:Tissue enhanced (appendix, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression most abundant in gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA071540
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, rectum, appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, colon)

GENE INFORMATION

Gene name

 NOXO1 (HGNC Symbol)

Synonyms

 P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28

Description

 NADPH oxidase organizer 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 1978917 - 1984192

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196408 (version 83.38)

Entrez gene

 124056

UniProt

 Q8NFA2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFA2

Antibodypedia

 NOXO1 antibodies

PROTEIN BROWSER
NOXO1-001
NOXO1-002
NOXO1-003
NOXO1-005
NOXO1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOXO1-001
ENSP00000346195
ENST00000354249
Q8NFA2 [Direct mapping]
NADPH oxidase organizer 1
Show all
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010310 [regulation of hydrogen peroxide metabolic process]
GO:0016176 [superoxide-generating NADPH oxidase activator activity]
GO:0019899 [enzyme binding]
GO:0022617 [extracellular matrix disassembly]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0043020 [NADPH oxidase complex]
GO:0060263 [regulation of respiratory burst]
Show all
 370 aa
40.7 kDa 		No 0
NOXO1-002
ENSP00000348435
ENST00000356120
Q8NFA2 [Direct mapping]
NADPH oxidase organizer 1
Show all
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010310 [regulation of hydrogen peroxide metabolic process]
GO:0016176 [superoxide-generating NADPH oxidase activator activity]
GO:0019899 [enzyme binding]
GO:0022617 [extracellular matrix disassembly]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0043020 [NADPH oxidase complex]
GO:0060263 [regulation of respiratory burst]
Show all
 371 aa
40.8 kDa 		No 0
NOXO1-003
ENSP00000380450
ENST00000397280
Q8NFA2 [Direct mapping]
NADPH oxidase organizer 1
Show all
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006801 [superoxide metabolic process]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010310 [regulation of hydrogen peroxide metabolic process]
GO:0016176 [superoxide-generating NADPH oxidase activator activity]
GO:0019899 [enzyme binding]
GO:0022617 [extracellular matrix disassembly]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0043020 [NADPH oxidase complex]
GO:0043085 [positive regulation of catalytic activity]
GO:0060263 [regulation of respiratory burst]
Show all
 376 aa
41.3 kDa 		No 0
NOXO1-005
ENSP00000456800
ENST00000566005
Q8NFA2 [Direct mapping]
NADPH oxidase organizer 1
Show all
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010310 [regulation of hydrogen peroxide metabolic process]
GO:0016176 [superoxide-generating NADPH oxidase activator activity]
GO:0019899 [enzyme binding]
GO:0022617 [extracellular matrix disassembly]
GO:0035091 [phosphatidylinositol binding]
GO:0042802 [identical protein binding]
GO:0043020 [NADPH oxidase complex]
GO:0060263 [regulation of respiratory burst]
Show all
 375 aa
41.1 kDa 		No 0
NOXO1-006
ENSP00000454644
ENST00000567471
H3BN18 [Direct mapping]
NADPH oxidase organizer 1
Show all
Predicted intracellular proteins
Show all
GO:0035091 [phosphatidylinositol binding]
Show all
 76 aa
8.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.