Cell atlas - ZNF124 - The Human Protein Atlas

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ZNF124

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleus

Human cell
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZNF124
Gene description	Zinc finger protein 124
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nuclear membrane.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nuclear membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA031127
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nuclear membrane.

Main location

Nucleus (approved), Nuclear membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031127	A-431	Nucleus
	HPA031127	A-431	Nuclear membrane
	HPA031127	U-2 OS	Nucleus
	HPA031127	U-2 OS	Nuclear membrane
	HPA031127	U-251 MG	Nucleoplasm
	HPA031127	U-251 MG	Nuclear membrane

GENE INFORMATION
Gene name	ZNF124 (HGNC Symbol)
Synonyms	HZF-16, HZF16
Description	Zinc finger protein 124 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2014]
Chromosome	1
Cytoband	q44
Chromosome location (bp)	247121975 - 247172016
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196418 (version 83.38)
Entrez gene	7678
UniProt	Q15973 (UniProt - Evidence at protein level)
neXtProt	NX_Q15973
Antibodypedia	ZNF124 antibodies

PROTEIN BROWSER

ZNF124-001	ZNF124-003	ZNF124-004	ZNF124-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF124-001 ENSP00000462445 ENST00000472531	Q15973 [Direct mapping] Zinc finger protein 124 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	73 aa 8.4 kDa	No	0
ZNF124-003 ENSP00000463191 ENST00000491356	J3QKQ6 [Direct mapping] Zinc finger protein 124 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	77 aa 8.8 kDa	No	0
ZNF124-004 ENSP00000340749 ENST00000340684	Q15973 [Direct mapping] Zinc finger protein 124 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	289 aa 33.3 kDa	No	0
ZNF124-009 ENSP00000440365 ENST00000543802	Q15973 [Direct mapping] Zinc finger protein 124 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	351 aa 40.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.