Expression of ADH1B in cancer - Summary

CANCER ATLAS

Gene description

Alcohol dehydrogenase 1B (class I), beta polypeptide

Protein class

Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA047814	HPA060902

GENE INFORMATION
Gene name	ADH1B (HGNC Symbol)
Synonyms	ADH2
Description	Alcohol dehydrogenase 1B (class I), beta polypeptide (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Chromosome	4
Cytoband	q23
Chromosome location (bp)	99304964 - 99321401
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196616 (version 83.38)
Entrez gene	125
UniProt	P00325 (UniProt - Evidence at protein level)
neXtProt	NX_P00325
Antibodypedia	ADH1B antibodies

PROTEIN BROWSER

ADH1B-001	ADH1B-004	ADH1B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADH1B-001 ENSP00000306606 ENST00000305046	P00325 [Direct mapping] Alcohol dehydrogenase 1B V9HW50 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 117 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004024 [alcohol dehydrogenase activity, zinc-dependent] GO:0005829 [cytosol] GO:0006069 [ethanol oxidation] GO:0006805 [xenobiotic metabolic process] GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	375 aa 39.8 kDa	No	0
ADH1B-004 ENSP00000425998 ENST00000506651	D6RHZ6 [Direct mapping] Alcohol dehydrogenase 1B Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	335 aa 35.4 kDa	No	0
ADH1B-201 ENSP00000486614 ENST00000625860	A0A0D9SFH8 [Direct mapping] Alcohol dehydrogenase 1B Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	335 aa 35.4 kDa	No	0