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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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ADH1B
  • premium

    TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Alcohol dehydrogenase 1B (class I), beta polypeptide

Protein class

Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA047814
HPA060902

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong cytoplasmic and nuclear staining was observed in liver cancers. Several cases of lymphomas along with a few ovarian, colorectal, breast and prostate cancers showed weak to moderate staining. Remaining cancer tissues were mainly negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few hepatocellular carcinomas displayed moderate cytoplasmic staining. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

ADH1B (HGNC Symbol)

Synonyms

ADH2

Description

Alcohol dehydrogenase 1B (class I), beta polypeptide (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Chromosome

4

Cytoband

q23

Chromosome location (bp)

99304964 - 99321401

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196616 (version 83.38)

Entrez gene

125

UniProt

P00325 (UniProt - Evidence at protein level)

neXtProt

NX_P00325

Antibodypedia

ADH1B antibodies

PROTEIN BROWSER

ADH1B-001
ADH1B-004
ADH1B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADH1B-001
ENSP00000306606
ENST00000305046
P00325 [Direct mapping]
Alcohol dehydrogenase 1B
V9HW50 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 117
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0005829 [cytosol]
GO:0006069 [ethanol oxidation]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
375 aa
39.8 kDa
No 0
ADH1B-004
ENSP00000425998
ENST00000506651
D6RHZ6 [Direct mapping]
Alcohol dehydrogenase 1B
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
335 aa
35.4 kDa
No 0
ADH1B-201
ENSP00000486614
ENST00000625860
A0A0D9SFH8 [Direct mapping]
Alcohol dehydrogenase 1B
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
335 aa
35.4 kDa
No 0

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The Human Protein Atlas project is funded
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