Moderate to strong cytoplasmic and nuclear staining was observed in liver cancers. Several cases of lymphomas along with a few ovarian, colorectal, breast and prostate cancers showed weak to moderate staining. Remaining cancer tissues were mainly negative.
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
P00325 [Direct mapping] Alcohol dehydrogenase 1B V9HW50 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 117
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)