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TCF4

GENERAL INFORMATION

Gene name

 TCF4

Gene description

 Transcription factor 4

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 57
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA025958 , CAB020722
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TCF4 (HGNC Symbol)

Synonyms

 bHLHb19, E2-2, ITF2, SEF2-1B

Description

 Transcription factor 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Aug 2011]

Chromosome

 18

Cytoband

 q21.2

Chromosome location (bp)

 55222331 - 55664787

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196628 (version 83.38)

Entrez gene

 6925

UniProt

 P15884 (UniProt - Evidence at protein level)

neXtProt

 NX_P15884

Antibodypedia

 TCF4 antibodies

PROTEIN BROWSER
«
TCF4-001
TCF4-002
TCF4-003
TCF4-004
TCF4-005
TCF4-006
TCF4-007
TCF4-008
TCF4-009
TCF4-010
TCF4-011
TCF4-012
TCF4-013
TCF4-014
TCF4-015
TCF4-016
TCF4-019
TCF4-020
TCF4-021
TCF4-023
TCF4-024
TCF4-025
TCF4-026
TCF4-027
TCF4-028
TCF4-029
TCF4-032
TCF4-033
TCF4-034
TCF4-038
TCF4-040
TCF4-041
TCF4-042
TCF4-043
TCF4-044
TCF4-045
TCF4-046
TCF4-049
TCF4-051
TCF4-053
TCF4-054
TCF4-056
TCF4-057
TCF4-059
TCF4-060
TCF4-061
TCF4-062
TCF4-063
TCF4-064
TCF4-065
TCF4-066
TCF4-067
TCF4-068
TCF4-070
TCF4-073
TCF4-074
TCF4-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TCF4-001
ENSP00000346440
ENST00000354452
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 671 aa
71.8 kDa 		No 0
TCF4-002
ENSP00000348374
ENST00000356073
P15884 [Direct mapping]
Transcription factor 4
A0A024R2C0 [Target identity:100%; Query identity:100%]
Transcription factor 4, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 667 aa
71.3 kDa 		No 0
TCF4-003
ENSP00000440731
ENST00000537578
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 647 aa
69.1 kDa 		No 0
TCF4-004
ENSP00000381382
ENST00000398339
E9PH57 [Direct mapping]
Transcription factor 4; Transcription factor 4, isoform CRA_e
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003682 [chromatin binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 773 aa
83.4 kDa 		No 0
TCF4-005
ENSP00000455346
ENST00000568740
H3BPJ7 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
Show all
 642 aa
68.5 kDa 		No 0
TCF4-006
ENSP00000457649
ENST00000564999
P15884 [Direct mapping]
Transcription factor 4
A0A024R2C0 [Target identity:100%; Query identity:100%]
Transcription factor 4, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 667 aa
71.3 kDa 		No 0
TCF4-007
ENSP00000445202
ENST00000540999
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 643 aa
68.6 kDa 		No 0
TCF4-008
ENSP00000455135
ENST00000568673
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 647 aa
69.1 kDa 		No 0
TCF4-009
ENSP00000439656
ENST00000543082
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 625 aa
67 kDa 		No 0
TCF4-010
ENSP00000455179
ENST00000561992
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 537 aa
57.4 kDa 		No 0
TCF4-011
ENSP00000441562
ENST00000544241
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 600 aa
64.6 kDa 		No 0
TCF4-012
ENSP00000454647
ENST00000570177
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 537 aa
57.4 kDa 		No 0
TCF4-013
ENSP00000439827
ENST00000537856
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 537 aa
57.4 kDa 		No 0
TCF4-014
ENSP00000456220
ENST00000562030
H3BRF7 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 179 aa
19.2 kDa 		No 0
TCF4-015
ENSP00000409447
ENST00000457482
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 511 aa
54.6 kDa 		No 0
TCF4-016
ENSP00000457765
ENST00000561831
P15884 [Direct mapping]
Transcription factor 4
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 507 aa
54.2 kDa 		No 0
TCF4-019
ENSP00000457263
ENST00000564403
H3BTP3 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
Show all
 677 aa
72.4 kDa 		No 0
TCF4-020
ENSP00000457082
ENST00000565124
H3BT95 [Direct mapping]
Transcription factor 4
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 168 aa
18.9 kDa 		No 0
TCF4-021
ENSP00000457392
ENST00000568169
H3BTZ0 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 280 aa
29.7 kDa 		No 0
TCF4-023
ENSP00000454328
ENST00000564343
H3BMC8 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 135 aa
14.5 kDa 		No 0
TCF4-024
ENSP00000454584
ENST00000565908
A0A075B723 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 209 aa
22.3 kDa 		No 0
TCF4-025
ENSP00000487171
ENST00000627685
A0A0D9SG61 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 204 aa
21.9 kDa 		No 0
TCF4-026
ENSP00000455163
ENST00000568147
H3BP59 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 165 aa
18 kDa 		No 0
TCF4-027
ENSP00000456983
ENST00000566514
H3BT24 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 287 aa
30.8 kDa 		No 0
TCF4-028
ENSP00000457113
ENST00000563824
H3BTC3 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 159 aa
17 kDa 		No 0
TCF4-029
ENSP00000454866
ENST00000562847
H3BNI2 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 56 aa
6.1 kDa 		No 0
TCF4-032
ENSP00000457245
ENST00000566777
H3BTM9 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 134 aa
14.5 kDa 		No 0
TCF4-033
ENSP00000486909
ENST00000628078
A0A0D9SFU5 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 207 aa
21.9 kDa 		No 0
TCF4-034
ENSP00000455304
ENST00000569012
H3BPG3 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 163 aa
17.7 kDa 		No 0
TCF4-038
ENSP00000468729
ENST00000570146
K7ESI6 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 166 aa
17.6 kDa 		No 0
TCF4-040
ENSP00000455450
ENST00000562543
G0LNT4 [Direct mapping]
Transcription factor 4; Transcription factor 4, isoform B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 139 aa
14.8 kDa 		No 0
TCF4-041
ENSP00000455418
ENST00000566286
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 664 aa
71.2 kDa 		No 0
TCF4-042
ENSP00000455261
ENST00000564228
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 596 aa
64.1 kDa 		No 0
TCF4-043
ENSP00000456802
ENST00000562638
G0LNT7 [Direct mapping]
Transcription factor 4; Transcription factor 4, isoform D
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 119 aa
12.8 kDa 		No 0
TCF4-044
ENSP00000455763
ENST00000570287
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 507 aa
54.1 kDa 		No 0
TCF4-045
ENSP00000456125
ENST00000566279
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 611 aa
65.3 kDa 		No 0
TCF4-046
ENSP00000454366
ENST00000567880
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 607 aa
64.8 kDa 		No 0
TCF4-049
ENSP00000486670
ENST00000629387
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 671 aa
71.8 kDa 		No 0
TCF4-051
ENSP00000487415
ENST00000626595
A0A0D9SGE5 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 221 aa
23.8 kDa 		No 0
TCF4-053
ENSP00000487150
ENST00000627784
A0A0D9SG55 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 156 aa
16.7 kDa 		No 0
TCF4-054
ENSP00000457747
ENST00000563888
H3BUQ3 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 146 aa
15.7 kDa 		No 0
TCF4-056
ENSP00000486111
ENST00000626425
A0A0D9SEX8 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 179 aa
19.1 kDa 		No 0
TCF4-057
ENSP00000486215
ENST00000630319
A0A0D9SF18 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 202 aa
21.5 kDa 		No 0
TCF4-059
ENSP00000487419
ENST00000630712
A0A0D9SGE7 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 129 aa
13.9 kDa 		No 0
TCF4-060
ENSP00000486072
ENST00000626584
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 451 aa
48.1 kDa 		No 0
TCF4-061
ENSP00000485755
ENST00000628636
A0A0D9SEK1 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 225 aa
23.6 kDa 		No 0
TCF4-062
ENSP00000487413
ENST00000625925
A0A0D9SGE4 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 135 aa
14.7 kDa 		No 0
TCF4-063
ENSP00000486148
ENST00000629343
A0A0D9SEZ3 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 236 aa
24.7 kDa 		No 0
TCF4-064
ENSP00000486974
ENST00000630828
A0A0D9SFX5 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 228 aa
25 kDa 		No 0
TCF4-065
ENSP00000458122
ENST00000568186
G0LNT7 [Direct mapping]
Transcription factor 4; Transcription factor 4, isoform D
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 119 aa
12.8 kDa 		No 0
TCF4-066
ENSP00000486405
ENST00000630268
A0A0D9SF97 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 155 aa
16.8 kDa 		No 0
TCF4-067
ENSP00000468277
ENST00000590810
A0A0E3D6N2 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 65 aa
7.1 kDa 		No 0
TCF4-068
ENSP00000455071
ENST00000562607
H3BNZ2 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 164 aa
17.7 kDa 		No 0
TCF4-070
ENSP00000487218
ENST00000630720
A0A0D9SG78 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 315 aa
32.8 kDa 		No 0
TCF4-073
ENSP00000487505
ENST00000626631
A0A0D9SGH7 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 81 aa
9 kDa 		No 0
TCF4-074
ENSP00000455984
ENST00000565018
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 583 aa
62.1 kDa 		No 0
TCF4-201
ENSP00000478549
ENST00000616053
P15884 [Direct mapping]
Transcription factor 4
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001011 [transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001087 [transcription factor activity, TFIIB-class binding]
GO:0001093 [TFIIB-class transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008022 [protein C-terminus binding]
GO:0042803 [protein homodimerization activity]
GO:0043425 [bHLH transcription factor binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0065004 [protein-DNA complex assembly]
GO:0070888 [E-box binding]
Show all
 583 aa
62.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.