Expression of SLC30A10 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 30, member 10

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017989

GENE INFORMATION
Gene name	SLC30A10 (HGNC Symbol)
Synonyms	DKFZp547M236, ZnT-10, ZNT8, ZRC1
Description	Solute carrier family 30, member 10 (HGNC Symbol)
Entrez gene summary	This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
Chromosome	1
Cytoband	q41
Chromosome location (bp)	219685427 - 219958647
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196660 (version 83.38)
Entrez gene	55532
UniProt	Q6XR72 (UniProt - Evidence at protein level)
neXtProt	NX_Q6XR72
Antibodypedia	SLC30A10 antibodies

PROTEIN BROWSER

SLC30A10-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC30A10-004 ENSP00000355893 ENST00000366926	Q6XR72 [Direct mapping] Zinc transporter 10 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006828 [manganese ion transport] GO:0008324 [cation transmembrane transporter activity] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0071577 [zinc II ion transmembrane transport] Show all	485 aa 52.7 kDa	No	6