Tissue expression of SLC30A10 - Summary - The Human Protein Atlas

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SLC30A10

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC30A10
Gene description	Solute carrier family 30, member 10
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (liver, duodenum)
GTEx:	Tissue enriched (liver)
FANTOM5:	Group enriched (liver, small intestine, colon)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA017989
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver, duodenum)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, small intestine, colon)

GENE INFORMATION
Gene name	SLC30A10 (HGNC Symbol)
Synonyms	DKFZp547M236, ZnT-10, ZNT8, ZRC1
Description	Solute carrier family 30, member 10 (HGNC Symbol)
Entrez gene summary	This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
Chromosome	1
Cytoband	q41
Chromosome location (bp)	219685427 - 219958647
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196660 (version 83.38)
Entrez gene	55532
UniProt	Q6XR72 (UniProt - Evidence at protein level)
neXtProt	NX_Q6XR72
Antibodypedia	SLC30A10 antibodies

PROTEIN BROWSER

SLC30A10-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC30A10-004 ENSP00000355893 ENST00000366926	Q6XR72 [Direct mapping] Zinc transporter 10 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006828 [manganese ion transport] GO:0008324 [cation transmembrane transporter activity] GO:0010043 [response to zinc ion] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0071577 [zinc II ion transmembrane transport] Show all	485 aa 52.7 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.