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Most of the cancer tissues were negative. Several cases of breast and endometrial cancers displayed weak to moderate cytoplasmic staining while a fraction of cells in several gliomas displayed moderate to strong cytoplasmic positivity.
GENE INFORMATION
Gene name
PDLIM7 (HGNC Symbol)
Synonyms
ENIGMA
Description
PDZ and LIM domain 7 (enigma) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]