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WDR45

CANCER ATLAS

Gene description

 WD repeat domain 45

Protein class

 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027562

GENE INFORMATION

Gene name

 WDR45 (HGNC Symbol)

Synonyms

 JM5, NBIA5, WDRX1, WIPI4

Description

 WD repeat domain 45 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 49071470 - 49101170

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196998 (version 83.38)

Entrez gene

 11152

UniProt

 Q9Y484 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9Y484

Antibodypedia

 WDR45 antibodies

PROTEIN BROWSER
«
WDR45-001
WDR45-002
WDR45-003
WDR45-004
WDR45-006
WDR45-009
WDR45-010
WDR45-012
WDR45-013
WDR45-018
WDR45-019
WDR45-020
WDR45-021
WDR45-022
WDR45-023
WDR45-026
WDR45-027
WDR45-028
WDR45-030
WDR45-033
WDR45-035
WDR45-036
WDR45-038
WDR45-039
WDR45-041
WDR45-044
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WDR45-001
ENSP00000365551
ENST00000376372
Q9Y484 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
A0A024QYX1 [Target identity:100%; Query identity:100%]
WD repeat domain 45, isoform CRA_a
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 360 aa
39.9 kDa 		No 0
WDR45-002
ENSP00000365543
ENST00000322995
Q9Y484 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
A0A024QYW6 [Target identity:100%; Query identity:100%]
WD repeat domain 45, isoform CRA_c
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 371 aa
41 kDa 		No 0
WDR45-003
ENSP00000489268
ENST00000634838
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 346 aa
38.4 kDa 		No 0
WDR45-004
ENSP00000356345
ENST00000367375
H0Y329 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 287 aa
31.8 kDa 		No 0
WDR45-006
ENSP00000419453
ENST00000486337
H7C5B4 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 86 aa
9.4 kDa 		No 0
WDR45-009
ENSP00000489040
ENST00000634671
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 59 aa
6.4 kDa 		No 0
WDR45-010
ENSP00000348848
ENST00000356463
Q9Y484 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 361 aa
39.9 kDa 		No 0
WDR45-012
ENSP00000419897
ENST00000485908
C9JYH8 [Direct mapping]
WD repeat domain 45, isoform CRA_e; WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 325 aa
36.2 kDa 		No 0
WDR45-013
ENSP00000420534
ENST00000465382
C9JE01 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 158 aa
18 kDa 		No 0
WDR45-018
ENSP00000365546
ENST00000376368
Q9Y484 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 361 aa
39.9 kDa 		No 0
WDR45-019
ENSP00000379913
ENST00000396681
G8JLI5 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 321 aa
35.7 kDa 		No 0
WDR45-020
ENSP00000417211
ENST00000473974
C9J471 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 256 aa
28.7 kDa 		No 0
WDR45-021
ENSP00000418919
ENST00000475880
C9J0A8 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 242 aa
27.1 kDa 		No 0
WDR45-022
ENSP00000419324
ENST00000476728
C9JVT3 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 138 aa
16 kDa 		No 0
WDR45-023
ENSP00000488986
ENST00000634559
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 289 aa
31.4 kDa 		No 0
WDR45-026
ENSP00000417754
ENST00000475977
H7C4N7 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 122 aa
13.4 kDa 		No 0
WDR45-027
ENSP00000397657
ENST00000423215
C9J7Q8 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 195 aa
21.8 kDa 		No 0
WDR45-028
ENSP00000420728
ENST00000474053
C9JBX7 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 213 aa
23.5 kDa 		No 0
WDR45-030
ENSP00000488972
ENST00000634944
A0A024QYX1 [Target identity:100%; Query identity:100%]
WD repeat domain 45, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 360 aa
39.9 kDa 		No 0
WDR45-033
ENSP00000489150
ENST00000634849
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 163 aa
18.5 kDa 		No 0
WDR45-035
ENSP00000489561
ENST00000634736
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 196 aa
21.3 kDa 		No 0
WDR45-036
ENSP00000418466
ENST00000471338
C9J5L0 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 175 aa
19.8 kDa 		No 0
WDR45-038
ENSP00000489128
ENST00000635666
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 277 aa
30.7 kDa 		No 0
WDR45-039
ENSP00000489080
ENST00000635003
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 293 aa
31.8 kDa 		No 0
WDR45-041
ENSP00000393640
ENST00000419567
C9JUS5 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 208 aa
23.4 kDa 		No 0
WDR45-044
ENSP00000365536
ENST00000376358
A6NM71 [Direct mapping]
Uncharacterized protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
 292 aa
31.5 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.