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WDR45

GENERAL INFORMATION

Gene name

 WDR45

Gene description

 WD repeat domain 45

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 26
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA027562
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 WDR45 (HGNC Symbol)

Synonyms

 JM5, NBIA5, WDRX1, WIPI4

Description

 WD repeat domain 45 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 49071470 - 49101170

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196998 (version 83.38)

Entrez gene

 11152

UniProt

 Q9Y484 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9Y484

Antibodypedia

 WDR45 antibodies

PROTEIN BROWSER
«
WDR45-001
WDR45-002
WDR45-003
WDR45-004
WDR45-006
WDR45-009
WDR45-010
WDR45-012
WDR45-013
WDR45-018
WDR45-019
WDR45-020
WDR45-021
WDR45-022
WDR45-023
WDR45-026
WDR45-027
WDR45-028
WDR45-030
WDR45-033
WDR45-035
WDR45-036
WDR45-038
WDR45-039
WDR45-041
WDR45-044
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WDR45-001
ENSP00000365551
ENST00000376372
Q9Y484 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
A0A024QYX1 [Target identity:100%; Query identity:100%]
WD repeat domain 45, isoform CRA_a
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 360 aa
39.9 kDa 		No 0
WDR45-002
ENSP00000365543
ENST00000322995
Q9Y484 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
A0A024QYW6 [Target identity:100%; Query identity:100%]
WD repeat domain 45, isoform CRA_c
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 371 aa
41 kDa 		No 0
WDR45-003
ENSP00000489268
ENST00000634838
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 346 aa
38.4 kDa 		No 0
WDR45-004
ENSP00000356345
ENST00000367375
H0Y329 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 287 aa
31.8 kDa 		No 0
WDR45-006
ENSP00000419453
ENST00000486337
H7C5B4 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 86 aa
9.4 kDa 		No 0
WDR45-009
ENSP00000489040
ENST00000634671
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 59 aa
6.4 kDa 		No 0
WDR45-010
ENSP00000348848
ENST00000356463
Q9Y484 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 361 aa
39.9 kDa 		No 0
WDR45-012
ENSP00000419897
ENST00000485908
C9JYH8 [Direct mapping]
WD repeat domain 45, isoform CRA_e; WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 325 aa
36.2 kDa 		No 0
WDR45-013
ENSP00000420534
ENST00000465382
C9JE01 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 158 aa
18 kDa 		No 0
WDR45-018
ENSP00000365546
ENST00000376368
Q9Y484 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 361 aa
39.9 kDa 		No 0
WDR45-019
ENSP00000379913
ENST00000396681
G8JLI5 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 321 aa
35.7 kDa 		No 0
WDR45-020
ENSP00000417211
ENST00000473974
C9J471 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 256 aa
28.7 kDa 		No 0
WDR45-021
ENSP00000418919
ENST00000475880
C9J0A8 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 242 aa
27.1 kDa 		No 0
WDR45-022
ENSP00000419324
ENST00000476728
C9JVT3 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 138 aa
16 kDa 		No 0
WDR45-023
ENSP00000488986
ENST00000634559
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 289 aa
31.4 kDa 		No 0
WDR45-026
ENSP00000417754
ENST00000475977
H7C4N7 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 122 aa
13.4 kDa 		No 0
WDR45-027
ENSP00000397657
ENST00000423215
C9J7Q8 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 195 aa
21.8 kDa 		No 0
WDR45-028
ENSP00000420728
ENST00000474053
C9JBX7 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 213 aa
23.5 kDa 		No 0
WDR45-030
ENSP00000488972
ENST00000634944
A0A024QYX1 [Target identity:100%; Query identity:100%]
WD repeat domain 45, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 360 aa
39.9 kDa 		No 0
WDR45-033
ENSP00000489150
ENST00000634849
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 163 aa
18.5 kDa 		No 0
WDR45-035
ENSP00000489561
ENST00000634736
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 196 aa
21.3 kDa 		No 0
WDR45-036
ENSP00000418466
ENST00000471338
C9J5L0 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 175 aa
19.8 kDa 		No 0
WDR45-038
ENSP00000489128
ENST00000635666
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 277 aa
30.7 kDa 		No 0
WDR45-039
ENSP00000489080
ENST00000635003
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 293 aa
31.8 kDa 		No 0
WDR45-041
ENSP00000393640
ENST00000419567
C9JUS5 [Direct mapping]
WD repeat domain phosphoinositide-interacting protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006497 [protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0019898 [extrinsic component of membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034497 [protein localization to pre-autophagosomal structure]
GO:0044804 [nucleophagy]
GO:0080025 [phosphatidylinositol-3,5-bisphosphate binding]
Show all
 208 aa
23.4 kDa 		No 0
WDR45-044
ENSP00000365536
ENST00000376358
A6NM71 [Direct mapping]
Uncharacterized protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
 292 aa
31.5 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.